| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
PI3 Kinase p110 beta Ser1070 |
| Specificity: |
PI3 Kinase p110 beta(Ser1070), This phosphorylation site is homologous to that of Ser1064 in Mouse and Ser1070 in Rat |
| Modification: |
Phosphorylation |
| Modification site: |
Ser1070 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human PI3 Kinase p110 beta around the phosphorylation site of Ser1070 |
| Gene ID: |
5291 |
| Swiss Prot: |
P42338 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Has a role in cell survival, Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, Involved in the early stage of autophagosome formation, May act as a scaffold, May also act downstream receptor tyrosine kinases, May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis, May have a role in cell migration, May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required, Mediator of oncogenic signal in cell lines lacking PTEN, Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity, PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, Plays a role in platelet activation signaling triggered by GPCRs, PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4, Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces, Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2), Required for the growth of ERBB2 and RAS driven tumors, Required in different signaling pathways for stable platelet adhesion and aggregation, The lipid kinase activity is necessary for its role in oncogenic transformation, activating signaling cascades involved in cell growth, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6, and lysophosphatidic acid, including AKT1 and PDPK1, independently of its lipid kinase activity to positively regulate autophagy, motility and morphology, proliferation, sphingosine 1-phosphate, survival, 4, 5)P2 (Phosphatidylinositol 4, 5-bisphosphate) to generate phosphatidylinositol 3, 5-trisphosphate (PIP3), Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ESI SKALP ELAFIN WAP3 WFDC14 cementoin |
| Also known as: |
PI3 Kinase p110 beta(Ser1070) Antibody |
| Other name: |
Anti-PI3 Kinase p110 beta(Ser1070) |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
PI3 Kinase p110 beta(Ser1070) |
| Short name: |
Anti-PI3 Kinase p110 beta(Ser1070) Fluor 594 |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-PI3 phosphorylation catalyst p110 b(Ser1070) |
| Identity: |
8947 |
| Gene: |
PI3 |
More about : PI3 |
| Long gene name: |
peptidase inhibitor 3 |
| Synonyms gene name: |
protease inhibitor 3, skin-derived , skin-derived (SKALP) peptidase inhibitor 3 |
| Synonyms name: |
skin-derived antileukoproteinase trappin-2 |
| Locus: |
20q13, 12 |
| Discovery year: |
1993-07-27 |
| GenBank acession: |
D13156 |
| Entrez gene record: |
5266 |
| Pubmed identfication: |
8287685 12206714 |
| RefSeq identity: |
NM_002638 |
| Classification: |
WAP four-disulfide core domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000032567 |