| Long name: |
PI3 Kinase p110 beta(Ser1070) Antibody |
| Also known as: |
PI3 Kinase p110 beta(Ser1070) Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PI3 Kinase p110 beta Ser1070 |
| Specificity: |
This phosphorylation site is homologous to that of Ser1064 in Mouse and Ser1070 in Rat, This is a highly specific antibody against PI3 Kinase p110 beta Ser1070 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser1070 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1020-1070/1070 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human PI3 Kinase p110 beta around the phosphorylation site of Ser1070 |
| Gene ID number: |
5291 |
| Swiss Prot: |
P42338 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Has a role in cell survival, Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, Involved in the early stage of autophagosome formation, May act as a scaffold, May also act downstream receptor tyrosine kinases, May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis, May have a role in cell migration, May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required, Mediator of oncogenic signal in cell lines lacking PTEN, Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity, PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, Plays a role in platelet activation signaling triggered by GPCRs, PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4, Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces, Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2), Required for the growth of ERBB2 and RAS driven tumors, Required in different signaling pathways for stable platelet adhesion and aggregation, The lipid kinase activity is necessary for its role in oncogenic transformation, activating signaling cascades involved in cell growth, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6, and lysophosphatidic acid, including AKT1 and PDPK1, independently of its lipid kinase activity to positively regulate autophagy, motility and morphology, proliferation, sphingosine 1-phosphate, survival, 4, 5)P2 (Phosphatidylinositol 4, 5-bisphosphate) to generate phosphatidylinositol 3, 5-trisphosphate (PIP3), Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, PIK3C1, PIK3CB, Phosphatidylinositol 4, PtdIns-3-kinase subunit beta, PtdIns-3-kinase subunit p110-beta, p110beta, 5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, 5-bisphosphate 3-kinase catalytic subunit beta isoform, Phosphatidylinositol 4 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PI3 Kinase p110 beta(Ser1070) |
| Short name: |
PI3 Kinase p110 beta(Ser1070) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PI3 phosphorylation catalyst p110 b(Ser1070) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8947 |
| Gene: |
PI3 |
More about : PI3 |
| Long gene name: |
peptidase inhibitor 3 |
| Synonyms gene name: |
protease inhibitor 3, skin-derived , skin-derived (SKALP) peptidase inhibitor 3 |
| Synonyms: |
ESI SKALP ELAFIN WAP3 WFDC14 cementoin |
| Synonyms name: |
skin-derived antileukoproteinase trappin-2 |
| Locus: |
20q13, 12 |
| Discovery year: |
1993-07-27 |
| GenBank acession: |
D13156 |
| Entrez gene record: |
5266 |
| Pubmed identfication: |
8287685 12206714 |
| RefSeq identity: |
NM_002638 |
| Classification: |
WAP four-disulfide core domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000032567 |