MEK7 Antibody / MAP2K7 / MKK7

Catalog number:	R31800 Buy Now
Price:	368 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	MEK7 Antibody / MAP2K7 / MKK7
Quantity:	0.1ml
Related search:	mkk mapkmkk gene residue tyr

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Category:	Antibody
Concentration:	2ml sterile DI water, 5mg/ml if reconstituted with 0
Form:	Antigen affinity purified
Conjugation:	Unconjugated
Clone:	Polyclonal antibody
Recognised antigen:	MEK7 / MAP2K7 / MKK7
Host animal:	Rabbit (Oryctolagus cuniculus)
Clonality:	Polyclonal (rabbit origin)
Species reactivity:	Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications:	IHC-P, WB
Recommended dilutions:	1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0
Notes:	Optimal dilution of the MKK7 antibody should be determined by the researcher
Intented use:	This MKK7 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #:	O14733
Purity:	Antigen affinity
Description:	Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway, Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines, MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue, MAPK9/JNK2 and MAPK10/JNK3, The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, With MAP2K4/MKK4, [UniProt], but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif, including the release cytochrome c, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, leading to apoptosis, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation, Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway
Immunogen:	Amino acids AASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPR of human MAP2K7 were used as the immunogen for the MKK7 antibody
Storage:	Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the MKK7 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene target:	MEK7 / MAP2K7 / MKK7
Short name:	MEK7 Antibody / MAP2K7 / MKK7
Technique:	antibodies against human proteins, antibodies for, Antibody
Alternative name:	MEK7 (Antibody to) / MAP2K7 / MKK7
Alternative technique:	antibodies
Identity:	6847
Gene:	MAP2K7 | More about : MAP2K7
Long gene name:	mitogen-activated protein kinase kinase 7
Synonyms gene:	PRKMK7
Synonyms:	MKK7 Jnkk2
Locus:	19p13, 2
Discovery year:	1998-04-28
GenBank acession:	AF006689
Entrez gene record:	5609
Pubmed identfication:	9312068
Classification:	Mitogen-activated protein kinase kinases
Havana BLAST/BLAT:	OTTHUMG00000137368

• #mkk
• #mapkmkk
• #gene
• #residue
• #tyr