| Long name: |
MKK7/ERK7 Primary Polyclonal Antibody |
| Also known as: |
MKK7/ERK7 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
MKK7/ERK7 |
| Specificity: |
This is a highly specific antibody against MKK7/ERK7 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
300-350/419 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MKK7 |
| Gene ID number: |
5609 |
| Swiss Prot: |
O14733 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway, Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines, MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue, MAPK9/JNK2 and MAPK10/JNK3, The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, With MAP2K4/MKK4, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif, including the release cytochrome c, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, leading to apoptosis, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation, Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Dual specificity mitogen-activated protein kinase kinase 7, JNK kinase 2, JNK-activating kinase 2, JNKK 2, JNKK2, MAP kinase kinase 7, MAP2K7, MAPK/ERK kinase 7, MAPKK 7, MAPKK7, MEK 7, MEK7, MKK7, PRKMK7, SAPK kinase 4, SAPKK-4, SAPKK4, SKK4, Stress-activated protein kinase kinase 4, c-Jun N-terminal kinase kinase 2, MEK |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MKK7/ERK7 |
| Short name: |
MKK7/ERK7 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MKK7/ERK7 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6847 |
| Gene: |
MAP2K7 |
More about : MAP2K7 |
| Long gene name: |
mitogen-activated protein kinase kinase 7 |
| Synonyms gene: |
PRKMK7 |
| Synonyms: |
MKK7 Jnkk2 |
| Locus: |
19p13, 2 |
| Discovery year: |
1998-04-28 |
| GenBank acession: |
AF006689 |
| Entrez gene record: |
5609 |
| Pubmed identfication: |
9312068 |
| Classification: |
Mitogen-activated protein kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000137368 |