MKK7/ERK7 Antibody, Biotin Conjugated

Catalog number:	bs-1979R-Biotin Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	MKK7/ERK7 Antibody, Biotin Conjugated
Quantity:	100ul
Related search:	antibody mapkmkk protein pathway residue mapkjnk transduction

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Long name:	Biotin Conjugated, MKK7/ERK7 Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Biotinylated
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	MKK7/ERK7
Specificity:	This is a highly specific antibody against MKK7/ERK7
Modification:	Unmodified
Modification site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	300-350/419
Subcellular location:	Nucleus, Cytoplasm
Source:	KLH conjugated synthetic peptide derived from human MKK7
Gene ID number:	5609
Swiss Prot:	O14733
Tested applications:	IHC-P, WB
Recommended dilutions:	IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway, Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines, MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue, MAPK9/JNK2 and MAPK10/JNK3, The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, With MAP2K4/MKK4, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif, including the release cytochrome c, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, leading to apoptosis, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation, Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Synonyms:	MKK7 Jnkk2
Properties:	Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	MKK7/ERK7 Conjugated
Short name:	Conjugated, MKK7/ERK7 Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Biotin
Alternative name:	biotinilated coupled, MKK7/ERK7 (Antibody to)
Alternative technique:	antibodies
Identity:	6847
Gene:	MAP2K7 | More about : MAP2K7
Long gene name:	mitogen-activated protein kinase kinase 7
Synonyms gene:	PRKMK7
Locus:	19p13, 2
Discovery year:	1998-04-28
GenBank acession:	AF006689
Entrez gene record:	5609
Pubmed identfication:	9312068
Classification:	Mitogen-activated protein kinase kinases
Havana BLAST/BLAT:	OTTHUMG00000137368

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