| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
MKK4 MEK4 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the MKK4 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This MKK4 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P45985 |
| Purity: |
Antigen affinity |
| Description: |
It has been shown to activate MAPK8/JNK1, It is mapped to 17p12, JNK2, JNKK1 and MKK4, MAP2K4 was a specific activator of JNK1, MAPK8, MAPK8IP3 and AKT1, MAPK9/JNK2, SEK1, This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family, This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli, This kinase is phosphorylated, also called MEK4, and MAPK14/p38, and it has been shown to interact with FLNC, and p38, and thus activated by MAP3K1/MEKK, but not MAPK1/ERK2 or MAPK3/ERK1, is an enzyme that in humans is encoded by the MAP2K4 gene, Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) |
| Immunogen: |
An amino acid sequence from the C-terminus of human MKK4/MEK4 (ELLKHPFILMYEERAVEVA) was used as the immunogen for this MKK4 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the MKK4 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
MKK4 MEK4 |
| Short name: |
MKK4 Antibody MEK4 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MKK4 (Antibody to) MEK4 |
| Alternative technique: |
antibodies |
| Identity: |
6844 |
| Gene: |
MAP2K4 |
More about : MAP2K4 |
| Long gene name: |
mitogen-activated protein kinase kinase 4 |
| Synonyms gene: |
SERK1 |
| Synonyms: |
MEK4 JNKK1 PRKMK4 MKK4 |
| Locus: |
17p12 |
| Discovery year: |
1997-11-11 |
| GenBank acession: |
L36870 |
| Entrez gene record: |
6416 |
| Pubmed identfication: |
7716521 |
| Classification: |
Mitogen-activated protein kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000178267 |