| Long name: |
ALEXA FLUOR 647 Conjugated, MEK4 (Thr261) Polyclonal Antibody |
| Also known as: |
Anti-MEK4 Thr261 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MEK4 Thr261 |
| Specificity: |
This is a highly specific antibody against MEK4 Thr261 |
| Modification: |
Phosphorylation |
| Modification Site: |
Thr261 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
240-280/399 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human MEK4 around the phosphorylation site of Thr261 |
| Gene ID Number: |
6416 |
| Swiss Prot: |
P45985 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway, MAP2K4 is required for maintaining peripheral lymphoid homeostasis, MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, MAPK12, MAPK13 and MAPK14, MAPK9/JNK2 and MAPK10/JNK3, The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, Whereas MAP2K7/MKK7 exclusively activates JNKs, With MAP2K7/MKK7, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif, including the release cytochrome c, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, leading to apoptosis, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs, Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
MEK4 JNKK1 PRKMK4 MKK4 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the MEK4 (Thr261) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
MEK4 (Thr261) |
| Short name: |
MEK4 (Thr261) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, MEK4 (Thr261) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6844 |
| Gene: |
MAP2K4 |
More about : MAP2K4 |
| Long gene name: |
mitogen-activated protein kinase kinase 4 |
| Synonyms gene: |
SERK1 |
| Locus: |
17p12 |
| Discovery year: |
1997-11-11 |
| GenBank acession: |
L36870 |
| Entrez gene record: |
6416 |
| Pubmed identfication: |
7716521 |
| Classification: |
Mitogen-activated protein kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000178267 |