| Also known as: |
TIM-2 |
| Other names: |
T cell immunoglobulin and mucin domain containing 2, T-cell immunoglobulin and mucin domain containing 2, T-cell immunoglobulin and mucin domain-containing protein 2, T-cell immunoglobulin and mucin domain-containing protein 2, T-cell membrane protein 2, T-cell membrane protein 2, TIM-2, TIMD-2, T-cell immunoglobulin and mucin domain-containing protein 2 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
TIM-2 |
| Other gene names: |
AA816106, AU019358, AU019662, C78111, G9D3, TIM-2, TIMD-2, Tim2, Tim2, Timd2, Timd2 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
RMT2-25 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Tim-2 also acts as a receptor for Semaphorin 4A, _x000D__x000D_Clone RMT2-25 has been shown to significantly enhance the proliferation of stimulated splenic B cells in vitro, _x000D__x000D_Studies using clone RMT2-25 in mouse, _x000D__x000D_Tim-2 acts as a negative regulator of Th2 cells, _x000D__x000D__x000D_, a transmembrane glycoprotein and member of the immunoglobulin superfamily, a transmembrane protein expressed on dendritic cells and B cells, and has been shown to enhance T cell activation, and is implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses, and preferentially up-regulated in Th2 cells and down-regulated in Th1 cells, developmentally in the 8-cell embryo and blastocyst, during early phase CIA (collagen-induced arthritis), expressed by activated lymphocytes, have shown that signaling by Tim-2 can influence the proliferation and antibody production of B cells, which plays a role in the guidance of axonal migration during neuronal development, TIM-2 Clone RMT2-25 specifically recognises mouse Tim-2 (T-cell immunoglobulin mucin 2) |
| Form/Appearance: |
Low Endotoxin (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, only, the antibody should be stored undiluted, Store the antibody should be stored at -20 degrees Celsius |
| Tested applications:: |
Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blot (WB), Functional Assay (FA) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
TIM-2: Endotoxin |
| Short name: |
RAT ANTI MOUSE TIM-2:Low Endotoxin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RAT antibody to MOUSE TIM-2:Low Endotoxin (Antibody to) |
| Alternative technique: |
antibodies |