| Also known as: |
TIM-4 |
| Other names: |
SMUCKLER, Spleen, T cell immunoglobulin and mucin domain containing 4, T-cell immunoglobulin and mucin domain containing 4, T-cell immunoglobulin and mucin domain-containing protein 4, T-cell immunoglobulin and mucin domain-containing protein 4, T-cell membrane protein 4, T-cell membrane protein 4, TIM-4, TIMD-4, knockout of lymphotoxin protein, knockout of lymphotoxin protein, mucin-containing, mucin-containing, smuckler, spleen, T-cell immunoglobulin and mucin domain-containing protein 4 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
TIM-4 |
| Other gene names: |
B430010N18Rik, SMUCKLER, TIM-4, TIMD-4, Tim4, Tim4, Timd4, Timd4 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
RMT4-54 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The TIM-4 gene locus is associated with predisposition to asthma in both mice and humans and may be considered as a candidate disease gene for asthma, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Studies have shown that clone RMT4-54 significantly inhibits the efficient phagocytosis of apoptotic cells by PRMs (peritoneal resident Mac1<, _x000D__x000D_Tim-4 is reported to be crucial for the phagocytosis of apoptotic cells by peritoneal macrophages, a transmembrane glycoprotein and member of the immunoglobulin superfamily, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on DCs, but not PEMs (peritoneal exudate Mac1<, cells), cells), enhances Th2 cell function, exclusively expressed by antigen-presenting cells, involved in T-cell expansion and cytokine production, which acts as the natural ligand of Tim-1, +<, +<, /sup>, /sup>, TIM-4 Clone RMT4-54 specifically recognises mouse Tim-4 (T-cell immunoglobulin mucin 4), sup>, sup> |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, the antibody should be stored undiluted, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS), Immunohistology - Paraffin (IHC), Immunofluorescence (IF) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
TIM-4 |
| Short name: |
RAT ANTI MOUSE TIM-4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RAT antibody to MOUSE TIM-4 (Antibody to) |
| Alternative technique: |
antibodies |