| Also known as: |
TIM-3 |
| Other names: |
HAVcr-2, Hepatitis A virus cellular receptor 2 homolog, T-cell immunoglobulin and mucin domain containing 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell membrane protein 3, T-cell membrane protein 3, TIM-3, TIMD-3, TIMD-3, hepatitis A virus cellular receptor 2, hepatitis A virus cellular receptor 2 homolog, hepatitis A virus cellular receptor 2 homolog |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
TIM-3 |
| Other gene names: |
HAVcr-2, Havcr2, TIM-3, TIMD-3, Tim3, Tim3, Timd3, Timd3, Havcr2 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
RMT3-23 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Tim-3 is also involved in the regulation of macrophage activation, _x000D__x000D_Studies have shown that clone RMT3-23 significantly inhibits the efficient phagocytosis of apoptotic cells by PEMs (peritoneal exudate Mac1+ cells) _x000D__x000D__x000D_, _x000D__x000D_Tim-3 acts as a negative regulator of Th1-mediated inflammatory diseases including GVHD, a transmembrane glycoprotein and member of the immunoglobulin superfamily, acts as a phagocytic receptor, and EAE (experimental autoimmune encephamyelitis), and has been shown to recognise apoptotic cells via the IgV domain, and is a receptor for galectin-9, but not by CD4+ Th2 cells or CD8+ Tc2 cells, preferentially expressed by differentiated CD4+ Th1 cells and CD8+ Tc1 (cytotoxic) cells, promotes immunological tolerance, shown to induce cell death of Th1 cells <, specifically recognises mouse T-cell immunoglobulin mucin 3, type I diabetes, /i>, /strong>, Rat anti Mouse Tim-3 clone RMT3-23<, TIM-3 <, i>, in vitro<, strong> |
| Form/Appearance: |
Phycoerythrin (RPE) - lyophilised), RPE (Purified IgG conjugated to R |
| Storage and shipping: |
After reconstitution Keep the antibody refrigerated at +4 degrees Celsius, DO NOT FREEZE, If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Shelf Life: 12 months from date of reconstitution, Temperature variations in the range between +1C to +7C are tolerable, Temperature variations in the range between +1C to +7C are tolerable, the antibody is photosensitive and should be protected from light, the antibody should be stored undiluted, Prior to reconstitution Keep the antibody refrigerated at +4 degrees Celsius |
| Tested applications:: |
Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
TIM-3:RPE |
| Short name: |
RAT ANTI MOUSE TIM-3:RPE Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RAT antibody to MOUSE TIM-3:RPE (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
18437 |
| Gene: |
HAVCR2 |
More about : HAVCR2 |
| Long gene name: |
hepatitis A virus cellular receptor 2 |
| Synonyms: |
Tim-3 TIM3 FLJ14428 TIMD3 CD366 |
| Synonyms name: |
T-cell immunoglobulin mucin family member 3 |
| Locus: |
5q33, 3 |
| Discovery year: |
2002-12-04 |
| GenBank acession: |
AK027334 |
| Entrez gene record: |
84868 |
| Pubmed identfication: |
11823861 |
| Classification: |
V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000130249 |