| Also known as: |
TIM-1 |
| Other names: |
HAVcr-1, Hepatitis A virus cellular receptor 1 homolog, KIM-1, Kidney injury molecule 1, T cell immunoglobulin and mucin domain-containing protein 1, T cell membrane protein 1, T-cell immunoglobulin and mucin domain containing 1, TIM-1, TIMD-1, TIMD-1, hepatitis A virus cellular receptor 1, hepatitis A virus cellular receptor 1 homolog, kidney injury molecule 1, t cell immunoglobulin and mucin domain-containing protein 1, t cell membrane protein 1, hepatitis A virus cellular receptor 1 homolog isoform b |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
TIM-1 |
| Other gene names: |
AI503787, HAVcr-1, Havcr1, KIM-1, KIM-1, Kim1, TIM-1, TIMD-1, Tim1, Tim1, Timd1, Timd1, Havcr1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
RMT1-10 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Tim-1 expression is greater on Th2 than Th1 cells, _x000D__x000D_Clone MBS239187-10 has been shown to promote Th2 responses, _x000D__x000D_Polymorphic forms of Tim-1 are associated with increased susceptibility to asthma, _x000D__x000D_Tim-1 is highly expressed by activated CD4+ T cells, a cell surface glycoprotein and member of the immunoglobulin superfamily, and acts as a positive/negative co-stimulatory molecule of T cell proliferation, and have implicated Tim-1 as a critical player in the development of atopic disease, and in particular airway hypersensitivity, and inhibit antigen-specific T cell proliferation, and is highly expressed in the liver (isoform Tim-1a) and the kidneys (isoform Tim-1b), and is the receptor for Tim-4, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on dendritic cells (DCs), cytokine production and tolerance abrogation, eczema and Rheumatoid arthritis, enhances Th2 cell function, expressed on APCs, in contrast to the agonistic function of many Tim-1 antibodies, which was first identified as the hepatitis A virus cellular receptor (HAVCR), TIM-1 Clone MBS239187-10 specifically recognises mouse Tim-1 (T-cell immunoglobulin mucin 1) |
| Form/Appearance: |
FITC (Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid) |
| Concentration: |
1 miligram per 1 mililiter, IgG concentration 0 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody is photosensitive and should be protected from light, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS) |
| Properties: |
FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, MBS mono FITC is highly sensitive to pH extremes, This MBS mono Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Conjugation: |
Anti-FITC Antibody |
| Gene target: |
TIM-1: |
| Short name: |
RAT ANTI MOUSE TIM-1:FITC Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, Antibody |
| Label: |
FITC |
| Alternative name: |
RAT antibody to MOUSE TIM-1:fluorecein (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
17866 |
| Gene: |
HAVCR1 |
More about : HAVCR1 |
| Long gene name: |
hepatitis A virus cellular receptor 1 |
| Synonyms: |
HAVCR-1 TIM-1 TIM1 HAVCR TIMD1 CD365 KIM1 |
| Synonyms name: |
T-cell immunoglobulin mucin family member 1 kidney injury molecule 1 |
| Locus: |
5q33, 3 |
| Discovery year: |
2002-12-04 |
| GenBank acession: |
AF043724 |
| Entrez gene record: |
26762 |
| Pubmed identfication: |
9658108 11725301 18273441 |
| Classification: |
CD molecules V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000163466 |