HPV16 E6 protein (2E3) Monoclonal Antibody, ALEXA FLUOR 350

Catalog number:	bsm-0990M-A350 Buy Now
Price:	332 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	HPV16 E6 protein (2E3) Monoclonal Antibody, ALEXA FLUOR 350
Quantity:	100ul
Related search:	protein alexa antibodies antibody host facs

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Long name:	ALEXA FLUOR 350 Conjugated, HPV16 E6 protein (2E3) Monoclonal Antibody
Also known as:	Anti-HPV16 E6 protein MAb ALEXA FLUOR 350
Category:	Conjugated Primary Antibodies
Conjugated with:	350, ALEXA FLUOR®
Host Organism:	Mouse (Mus musculus)
Target Antigen:	HPV16 E6 protein
Specificity:	This is a highly specific antibody against HPV16 E6 protein
Modification:	Unmodified
Modification Site:	None
Clonality:	Monoclonal
Clone:	2000
Concentration:	1ug per 1ul
Immunogen range:	85-158/158
Source:	KLH conjugated synthetic peptide derived from HPV16 E6 protein
Gene ID Number:	1489078
Swiss Prot:	P03126
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Virus
Cross-reactive species details:	HPV16
Background of the antigen:	Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development, E6 also inhibits immune response by interacting with host IRF3 and TYK2, E6 associates with host E6-AP ubiquitin-protein ligase, Fas-associated death domain-containing protein (FADD) and procaspase 8, In turn, Other cellular targets including Bak, The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization, These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway, a repressor of human telomerase reverse transcriptase (hTERT), and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation, are degraded by E6/E6AP causing inhibition of apoptosis, Plays a major role in the induction and maintenance of cellular transformation
Purification:	Purified by Protein G
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	343nm/442nm
Synonyms:	E6, Protein E6
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	ALEXA FLUOR 350, Alexa Fluor
About:	Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target:	HPV16 E6 protein (2E3) Monoclonal
Short name:	HPV16 E6 protein (2E3) Monoclonal Antibody
Technique:	Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 350
Alternative name:	ALEXA FLUOR 350, HPV16 E6 protein (2E3) monoclonal (Antibody to)
Alternative technique:	antibodies

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