| Long name: |
ALEXA FLUOR 647 Conjugated, HPV16 E6 protein (2E3) Monoclonal Antibody |
| Also known as: |
Anti-HPV16 E6 protein MAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Mouse (Mus musculus) |
| Target Antigen: |
HPV16 E6 protein |
| Specificity: |
This is a highly specific antibody against HPV16 E6 protein |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Monoclonal |
| Clone: |
2000 |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
85-158/158 |
| Source: |
KLH conjugated synthetic peptide derived from HPV16 E6 protein |
| Gene ID Number: |
1489078 |
| Swiss Prot: |
P03126 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Virus |
| Cross-reactive species details: |
HPV16 |
| Background of the antigen: |
Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development, E6 also inhibits immune response by interacting with host IRF3 and TYK2, E6 associates with host E6-AP ubiquitin-protein ligase, Fas-associated death domain-containing protein (FADD) and procaspase 8, In turn, Other cellular targets including Bak, The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization, These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway, a repressor of human telomerase reverse transcriptase (hTERT), and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation, are degraded by E6/E6AP causing inhibition of apoptosis, Plays a major role in the induction and maintenance of cellular transformation |
| Purification: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
E6, Protein E6 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the HPV16 E6 protein (2E3) Monoclonal Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
HPV16 E6 protein (2E3) Monoclonal |
| Short name: |
HPV16 E6 protein (2E3) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, HPV16 E6 protein (2E3) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |