| Long name: |
ALEXA FLUOR 647 Conjugated, PHD2 Polyclonal Antibody |
| Also known as: |
Anti-PHD2 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PHD2 |
| Specificity: |
This is a highly specific antibody against PHD2 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
30-70/426 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PHD2 |
| Gene ID Number: |
54583 |
| Swiss Prot: |
Q9GZT9 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Also hydroxylates HIF2A, CODD) of HIF1A, EGLN1 is the most important isozyme under normoxia and, Has a preference for the CODD site for both HIF1A and HIF1B, Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex, Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, Target proteins are preferencially recognized via a LXXLAP motif, Under hypoxic conditions, and C-terminal, and increased expression of hypoxy-inducible genes, heterodimerization with HIF1B, involved in various hypoxia-influenced processes such as angiogenesis in retinal and cardiac functionality, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins, through regulating the stability of HIF1, under normoxic conditions, Cellular oxygen sensor that catalyzes |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
SM-20 PHD2 ZMYND6 HIFPH2 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the PHD2 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
PHD2 |
| Short name: |
PHD2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, PHD2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1232 |
| Gene: |
EGLN1 |
More about : EGLN1 |
| Long gene name: |
egl-9 family hypoxia inducible factor 1 |
| Synonyms gene: |
C1orf12 |
| Synonyms gene name: |
EGL nine (C, elegans) egl-9 family hypoxia-inducible factor 1 , elegans) homolog 1 egl nine homolog 1 (C |
| Synonyms name: |
HIF prolyl hydroxylase 2 |
| Locus: |
1q42, 2 |
| Discovery year: |
2000-06-16 |
| GenBank acession: |
AJ310543 |
| Entrez gene record: |
54583 |
| Pubmed identfication: |
11056053 |
| RefSeq identity: |
NM_022051 |
| Classification: |
Zinc fingers MYND-type |
| Havana BLAST/BLAT: |
OTTHUMG00000038027 |