| Long name: |
ALEXA FLUOR 488 Conjugated, SMC1 (Ser360) Polyclonal Antibody |
| Also known as: |
Anti-SMC1 Ser360 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SMC1 Ser360 |
| Specificity: |
This is a highly specific antibody against SMC1 Ser360 |
| Modification: |
Phosphorylation |
| Modification Site: |
Ser360 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human SMC1 around the phosphorylation site of Ser360 |
| Gene ID Number: |
8243 |
| Tested applications: |
IF(IHC-P), FCM |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), FCM(1:20-100) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
A number of cellular factors interact with hSMC1/hSMC3 during cell cycle, A subset of hSMC1/hSMC3 is localized to spindle poles, DNA recombination and repair and global transcriptional repression, Human cohesion complex associates with chromosomes which peaks at S phase and dissociates from chromosomes during G2/M transition, In addition, SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells, Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase, The chromosome proteins are conserved in eukaryotes and can lead to mitotic chromosome segregation defects, The major population of hSMC1/hSMC3 is in a compex with hRAD21 forming the human cohesion complex, a subpopulation of hSMC1/hSMC3 associates tightly with nuclear matrix and centrosomes during interphase, hSMC1/hSMC3 is required for spindle aster formation in vitro and reacts with nuclear mitotic apparatus protein in vivo, including mitotic chromosome organization, spindles and kinetochores during mitosis when cohesin is in the cytoplasm, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics, Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
SMC 1, SMC1, SMC1A, SMC1A_HUMAN, SMC1B, SMC1BETA, SMC1L1, SMC1L2, SMC1alpha, SMC1alpha protein, SMC1beta protein, SMCB, Segregation of mitotic chromosomes 1, Segregation of mitotic chromosomes like 1, Structural Maintenance of Chromosomes-1 Like 1, Structural maintenance of chromosome 1 like 1 protein, Structural maintenance of chromosome 1 like 2 protein, Structural maintenance of chromosomes 1A, Structural maintenance of chromosomes 1B, structural maintenance of chromosomes 1-like 2 yeast, CDLS2 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the SMC1 (Ser360) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
SMC1 (Ser360) |
| Short name: |
SMC1 (Ser360) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, SMC1 (Ser360) (Antibody to) |
| Alternative technique: |
antibodies |