| Long name: |
ALEXA FLUOR 647 Conjugated, PLK1 (Ser137) Polyclonal Antibody |
| Also known as: |
Anti-PLK1 Ser137 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PLK1 Ser137 |
| Specificity: |
This is a highly specific antibody against PLK1 Ser137 |
| Modification: |
Phosphorylation |
| Modification Site: |
Ser137 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
110-160/603 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human PLK1 around the phosphorylation site of Ser137 |
| Gene ID Number: |
5347 |
| Swiss Prot: |
P53350 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Contributes to the regulation of AURKA function, NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, Phosphorylates BORA, Phosphorylates NEDD1, Phosphorylates SGOL1, Phosphorylates both ECT2 and RACGAP1, Promotes the central spindle recruitment of ECT2, Regulates TP53 stability through phosphorylation of TOPORS, Required for kinetochore localization of BUB1B, Required for recovery after DNA damage checkpoint and entry into mitosis, Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function, an important step for spindle formation, and the regulation of mitotic exit and cytokinesis, and thereby promotes the degradation of BORA, and thereby stimulates their interaction that is essential for the cleavage furrow formation, including the regulation of centrosome maturation and spindle assembly, the inactivation of APC/C inhibitors, the removal of cohesins from chromosome arms, Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the PLK1 (Ser137) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
PLK1 (Ser137) |
| Short name: |
PLK1 (Ser137) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, PLK1 (Ser137) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9077 |
| Gene: |
PLK1 |
More about : PLK1 |
| Long gene name: |
polo like kinase 1 |
| Synonyms gene: |
PLK |
| Synonyms gene name: |
polo-like kinase (Drosophila) polo-like kinase 1 |
| Locus: |
16p12, 2 |
| Discovery year: |
1994-07-25 |
| Entrez gene record: |
5347 |
| Pubmed identfication: |
8127874 |
| RefSeq identity: |
NM_005030 |
| Havana BLAST/BLAT: |
OTTHUMG00000096984 |