| Long name: |
YB1 Primary Polyclonal Antibody |
| Also known as: |
YB1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
YB1 |
| Specificity: |
This is a highly specific antibody against YB1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
120-170/324 |
| Subcellular location: |
Nucleus, Secreted, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human YBX-1 |
| Gene ID number: |
4904 |
| Swiss Prot: |
P67809 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Binds and stabilizes cytoplasmic mRNA, Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro, Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), Binds to splice sites in pre-mRNA and regulates splice site selection, Component of the CRD-mediated complex that promotes MYC mRNA stability, Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity), Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro), Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7', May play a role in DNA repair, Promotes separation of DNA strands that contain mismatches or are modified by cisplatin, Regulates the transcription of numerous genes, The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation, such as MDR1 and HLA class II genes, Mediates pre-mRNA alternative splicing regulation |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BP-8, CBF-A, CCAAT-binding transcription factor I subunit A, CSDA2, CSDB, DBPB, DNA-binding protein B, EFI-A, Enhancer factor I subunit A, MDR-NF1, NSEP-1, NSEP1, Nuclease-sensitive element-binding protein 1, Y-box transcription factor, Y-box-binding protein 1, YB-1, YBX1, YB1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
YB1 |
| Short name: |
YB1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
YB1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8014 |
| Gene: |
YBX1 |
More about : YBX1 |
| Long gene name: |
Y-box binding protein 1 |
| Synonyms gene: |
NSEP1 |
| Synonyms gene name: |
nuclease sensitive element binding protein 1 |
| Synonyms: |
YB-1 YB1 DBPB NSEP-1 MDR-NF1 BP-8 CSDB CSDA2 |
| Locus: |
1p34, 2 |
| Discovery year: |
1993-10-20 |
| GenBank acession: |
BC013838 |
| Entrez gene record: |
4904 |
| Pubmed identfication: |
1891370 3174636 |
| RefSeq identity: |
NM_004559 |
| Classification: |
Y box binding proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000007523 |