| Alternative name 1: |
Clone: ZAP-03, Mab anti-, ZAP70 |
| Alternative name 2: |
Clone: ZAP-03, Mab antibody-, ZAP70 |
| Alternative name 3: |
Clone: ZAP-03, Mab antibody-, ZAP70 |
| Alternative name 4: |
anti-ZAP70 Clone: ZAP-03 |
| Alternative name 5: |
ZAP70 Clone: ZAP-03 |
| Clonality: |
Monoclonal Antibody |
| Description: |
Amongst the advantages of the monoclonal antibodies are: the fact that while the hybridoma takes a bit longer to be produced, If used correctly and according the protocol, in comparison to the polyclonal antibodies monoclonal antibodies are highly specific to a given epitope and can be used in applications where specific targeting is required, once the line is ready there is virtually an endless supply of these antibodie throughout time with little to no variations in recognition sites of the antigen in different batches, this antibody will provide excellent and reproducible results with guaranteed success for the tested and confirmed applications, This is a monoclonal antibody which is greatly purified and with high binding affinity for the antigen that it is risen against |
| Storage and handling: |
Antibodies in a liquid form can be shipped and stored for a short period of time at +4 degrees Celsius, antibodies that are lyophilized can be transported at ambient temperature and stored for short terms at +4 degrees Celsius, for long term storage (up to one year) 25-50% glycerol or ethylene glycol should be added and then the container has to be stored at -20°, for longer periods - at -20 , C, Generally |
| Advisory: |
For antibodies in a liquid form or reconstituted lyophilized antibodies small amounts of the soultion could be captured on the cap or the walls of the container, Right before use you could briefly centrifuge the vial to collect all of the solution on the bottom, To keep the quality and the affinity of the antibody cycles of freezing and thawing should be avoided |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| French translation: |
anticorps |
| Gene target: |
Monoclonal ZAP-03, ZAP70 |
| Short name: |
Mouse Monoclonal antibody- Clone: ZAP-03, ZAP70 |
| Technique: |
Monoclonals or monoclonal antibodies, mouses, Mouse |
| Species: |
Mouses, Mouse |
| Alternative name: |
Mouse monoclonal (Antibody to)-, clonality: ZAP-03, zeta-chain (TCR) associated protein kinase 70kDa |
| Alternative technique: |
murine |
| Alternative to gene target: |
Cell surfaces, SRK and STCD and STD and TZK and ZAP-70, ZAP70 and IDBG-62509 and ENSG00000115085 and 7535, ZAP70 and IDBG-629842 and ENSBTAG00000005892 and 504509, Zap70 and IDBG-145089 and ENSMUSG00000026117 and 22637, this GO :0001772 and immunological synapse and cellular component this GO :0001784 and phosphotyrosine binding and molecular function this GO :0002250 and adaptive immune response and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004715 and non-membrane spanning protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006955 and immune response and biological process this GO :0016772 and transferase activity, this GO :0001784 : phosphotyrosine binding, this GO :0001784 : phosphotyrosine binding and also this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004715 : non-membrane spanning protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004672 : protein kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004715 : non-membrane spanning protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0030217 and T cell differentiation and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0042101 and T cell receptor complex and cellular component this GO :0042110 and T cell activation and biological process this GO :0042113 and B cell activation and biological process this GO :0043366 and beta selection and biological process this GO :0045059 and positive thymic T cell selection and biological process this GO :0045060 and negative thymic T cell selection and biological process this GO :0045061 and thymic T cell selection and biological process this GO :0045121 and membrane raft and cellular component this GO :0045582 and positive regulation of T cell differentiation and biological process this GO :0046638 and positive regulation of alpha-beta T cell differentiation and biological process this GO :0046641 and positive regulation of alpha-beta T cell proliferation and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0050850 and positive regulation of calcium-mediated signaling and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0070489 and T cell aggregation and biological process this GO :0072678 and T cell migration and biological process, zeta-chain (TCR) associated protein kinase 70kDa |
| Identity: |
12858 |
| Gene: |
ZAP70 |
More about : ZAP70 |
| Long gene name: |
zeta chain of T-cell receptor associated protein kinase 70 |
| Synonyms gene: |
SRK |
| Synonyms gene name: |
zeta-chain (TCR) associated protein kinase (70 kD) zeta-chain (TCR) associated protein kinase 70kDa zeta chain of T cell receptor associated protein kinase 70kDa zeta chain of T cell receptor associated protein kinase 70 |
| Synonyms: |
ZAP-70 STD |
| Synonyms name: |
tyrosine-protein kinase ZAP-70 |
| Locus: |
2q11, 2 |
| Discovery year: |
1995-05-16 |
| GenBank acession: |
L05148 |
| Entrez gene record: |
7535 |
| Pubmed identfication: |
1423621 |
| RefSeq identity: |
NM_001079 |
| Classification: |
SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000153060 |
| Locus Specific Databases: |
ZAP70base: Mutation registry for autosomal recessive ZAP70 immunodeficiency LRG_126 |