| Long name: |
SLP76 Primary Polyclonal Antibody |
| Also known as: |
SLP76 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
SLP76 |
| Specificity: |
This is a highly specific antibody against SLP76 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SLP76 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Although SLP-76 does not contain a motif that would indicate it to be a member of the tyrosine, However, Overexpression of Vav or SLP-76 in Jurkat cells leads to NFAT activation and IL-2 production, The discovery of SLP-76 represents an important step in elucidating the mechanism of Vav transformation and TCR-mediated NFAT activation, Vav and SLP-76 synergize to induce a robust basal and TCR-mediated IL-2 response, Vav contains a single SH2 domain that is required for its association with the T cell receptor (TCR), When co-expressed, it does contain several putative SH2/SH3-binding domains and has been shown to physically associate with the adapter protein GRB2 as well as PLC g1, serine/threonine or lipid kinase families, the biochemical basis of Vavâ, &euro, &trade, The translational product of the Vav proto-oncogene is exclusively expressed in cells of hematopoietic origin and is critical for lymphocyte development and activation, s function is unclear |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CG8697, LCP 2, LCP 2, LCP2, LCP2_HUMAN, Lymphocyte Cytosolic Protein 2, Lymphocyte Cytosolic Protein 2, SH2 Domain Containing Leukocyte Protein 76 KD, SH2 domain containing leukocyte protein of 76kD, SH2 domain containing leukocyte protein of 76kDa, SH2 domain-containing leukocyte protein of 76 kDa, SLP 76, SLP 76, SLP 76 tyrosine phosphoprotein, SLP-76 tyrosine phosphoprotein, SLP76, SLP76 tyrosine phosphoprotein, 76 kDa tyrosine phosphoprotein |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
SLP76 |
| Short name: |
SLP76 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SLP76 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6529 |
| Gene: |
LCP2 |
More about : LCP2 |
| Long gene name: |
lymphocyte cytosolic protein 2 |
| Synonyms gene: |
SLP76 |
| Synonyms gene name: |
lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) |
| Synonyms: |
SLP-76 |
| Synonyms name: |
76 kDa tyrosine phosphoprotein SH2 domain-containing leukocyte protein of 76kD |
| Locus: |
5q35, 1 |
| Discovery year: |
1996-03-12 |
| Entrez gene record: |
3937 |
| Pubmed identfication: |
7706237 |
| RefSeq identity: |
NM_005565 |
| Classification: |
SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000163121 |