| Long name: |
ASAH1 Primary Polyclonal Antibody |
| Also known as: |
ASAH1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ASAH1 |
| Specificity: |
This is a highly specific antibody against ASAH1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Acid ceramidase subunit beta |
| Gene ID number: |
427 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma, Effected individuals experience early onset joint problems and neurological problems, In addition to ceramide hydrolysis, Interestingly, a hallmark of Farber disease, and deficiency leads to accumulation of ceramide in tissues, for hydrolysis the pH optimum is 4, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism, owing to mutations in the acid ceramidase gene, pH regulates which reaction is favored, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates, whereas for the reverse reaction favors a pH of 5, 5, 5, Acid ceramidase catalyzes the degradation of ceramide in normal tissues |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ACDase, ASAH, ASAH 1, ASAH1, ASAH1_HUMAN, Acid CDase, Acid ceramidase, Acid ceramidase precursor, Acid ceramidase subunit beta, Acylsphingosine deacylase, FLJ21558, FLJ22079, N acylsphingosine amidohydrolase, N acylsphingosine amidohydrolase 1, N acylsphingosine amidohydrolase acid ceramidase 1, N-acylsphingosine amidohydrolase, PHP, PHP32, Putative 32 kDa heart protein, AC |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ASAH1 |
| Short name: |
ASAH1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
ASAH1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
735 |
| Gene: |
ASAH1 |
More about : ASAH1 |
| Long gene name: |
N-acylsphingosine amidohydrolase 1 |
| Synonyms gene: |
ASAH |
| Synonyms gene name: |
N-acylsphingosine amidohydrolase (acid ceramidase) |
| Synonyms: |
AC PHP32 FLJ21558 ACDase |
| Synonyms name: |
acylsphingosine deacylase acid ceramidase |
| Locus: |
8p22 |
| Discovery year: |
1997-08-22 |
| GenBank acession: |
U70063 |
| Entrez gene record: |
427 |
| Pubmed identfication: |
8955159 10610716 |
| RefSeq identity: |
NM_004315 |
| Havana BLAST/BLAT: |
OTTHUMG00000096997 |