| Long name: |
Biotin Conjugated, SPG3A/Atlastin Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SPG3A/Atlastin |
| Specificity: |
This is a highly specific antibody against SPG3A/Atlastin |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human SPG3A/Atlastin |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness, Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration, Mutations in the Atlastin gene (SPG3A) account for approximately 10% of all autosomal dominant HSPs, Spastin, The Atlastin proteins, This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development, a microtubule (MT)-severing AAA ATPase, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance, integral membrane proteins that function as GTPases, is a binding partner of Atlastin that is involved in membrane dynamics, while mutations in the Spastin gene (SPG4) account for almost 40%, Atlastins are Golgi-localized |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
FSP1 AD-FSP |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
SPG3A/Atlastin Conjugated |
| Short name: |
Conjugated, SPG3A/Atlastin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, SPG3A/Atlastin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11231 |
| Gene: |
ATL1 |
More about : ATL1 |
| Long gene name: |
atlastin GTPase 1 |
| Synonyms gene: |
SPG3 SPG3A |
| Synonyms gene name: |
spastic paraplegia 3A (autosomal dominant) |
| Synonyms name: |
atlastin |
| Locus: |
14q22, 1 |
| Discovery year: |
1993-10-28 |
| GenBank acession: |
AF131801 |
| Entrez gene record: |
51062 |
| Pubmed identfication: |
8252041 7825576 |
| Havana BLAST/BLAT: |
OTTHUMG00000140297 |
| Locus Specific Databases: |
LRG_360 |