| Long name: |
ALEXA FLUOR 647 Conjugated, SPG3A/Atlastin Polyclonal Antibody |
| Also known as: |
Anti-SPG3A/Atlastin PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
SPG3A/Atlastin |
| Specificity: |
This is a highly specific antibody against SPG3A/Atlastin |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SPG3A/Atlastin |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness, Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration, Mutations in the Atlastin gene (SPG3A) account for approximately 10% of all autosomal dominant HSPs, Spastin, The Atlastin proteins, This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development, a microtubule (MT)-severing AAA ATPase, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance, integral membrane proteins that function as GTPases, is a binding partner of Atlastin that is involved in membrane dynamics, while mutations in the Spastin gene (SPG4) account for almost 40%, Atlastins are Golgi-localized |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
FSP1 AD-FSP |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the SPG3A/Atlastin Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
SPG3A/Atlastin |
| Short name: |
SPG3A/Atlastin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, SPG3A/Atlastin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11231 |
| Gene: |
ATL1 |
More about : ATL1 |
| Long gene name: |
atlastin GTPase 1 |
| Synonyms gene: |
SPG3 SPG3A |
| Synonyms gene name: |
spastic paraplegia 3A (autosomal dominant) |
| Synonyms name: |
atlastin |
| Locus: |
14q22, 1 |
| Discovery year: |
1993-10-28 |
| GenBank acession: |
AF131801 |
| Entrez gene record: |
51062 |
| Pubmed identfication: |
8252041 7825576 |
| Havana BLAST/BLAT: |
OTTHUMG00000140297 |
| Locus Specific Databases: |
LRG_360 |