| Long name: |
Cy5, 5 Conjugated, UNC5D/UNC5H4 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Cy5, 5, 5, Cy5 |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
UNC5D/UNC5H4 |
| Specificity: |
This is a highly specific antibody against UNC5D/UNC5H4 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from human UNC5H4 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Additionally, In the absence of netrin-1, The expression of UNC5H receptors is down-regulated in multiple carcinomas, This activity is blocked by the binding of netrin-1, Two isoforms of UNC5H4 exist due to alternative splicing events, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, UNC5H4, also known as UNC5D (unc-5 homolog D), and kidney cancers, breast, but mutation of these receptors provides a potential mechanism for tumorigenicity, including colorectal, is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family, lung, ovary, stomach, uterus, when cleaved by a caspase to produce an intracellular fragment containing a death domain, The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells, UNC5H receptors induce apoptosis |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
675nm/694nm |
| Synonyms: |
KIAA1777 Unc5h4 |
| Properties: |
Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Conjugated: |
These antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths |
| Gene target: |
UNC5D/UNC5H4 Conjugated |
| Short name: |
Conjugated, UNC5D/UNC5H4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
5, Cy5 |
| Alternative name: |
cyanine 5, elegans)/UNC5H4 (Antibody to), 5 coupled, unc-5 homolog D (C |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, UNC5D and IDBG-16693 and ENSG00000156687 and 137970, UNC5D and IDBG-628993 and ENSBTAG00000010241 and 520004, Unc5d and IDBG-146351 and ENSMUSG00000063626 and 210801, elegans), protein binding, this GO :0005515 and protein binding and molecular function this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0009986 and cell surface and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0021859 and pyramidal neuron differentiation and biological process this GO :2001222 and regulation of neuron migration and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, unc-5 homolog D (C |
| Identity: |
18634 |
| Gene: |
UNC5D |
More about : UNC5D |
| Long gene name: |
unc-5 netrin receptor D |
| Synonyms gene name: |
elegans) , unc-5 homolog D (C |
| Synonyms name: |
Netrin receptor UNC5D Protein unc-5 homolog 4 Protein unc-5 homolog D |
| Locus: |
8p12 |
| Discovery year: |
2002-05-13 |
| GenBank acession: |
AB055056 |
| Entrez gene record: |
137970 |
| Pubmed identfication: |
18402767 |
| Classification: |
I-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000157145 |