| Long name: |
ALEXA FLUOR 647 Conjugated, UNC5D/UNC5H4 Polyclonal Antibody |
| Also known as: |
Anti-UNC5D/UNC5H4 PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
UNC5D/UNC5H4 |
| Specificity: |
This is a highly specific antibody against UNC5D/UNC5H4 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human UNC5H4 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Additionally, In the absence of netrin-1, The expression of UNC5H receptors is down-regulated in multiple carcinomas, This activity is blocked by the binding of netrin-1, Two isoforms of UNC5H4 exist due to alternative splicing events, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, UNC5H4, also known as UNC5D (unc-5 homolog D), and kidney cancers, breast, but mutation of these receptors provides a potential mechanism for tumorigenicity, including colorectal, is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family, lung, ovary, stomach, uterus, when cleaved by a caspase to produce an intracellular fragment containing a death domain, The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells, UNC5H receptors induce apoptosis |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
KIAA1777 Unc5h4 |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the UNC5D/UNC5H4 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Gene target: |
UNC5D/UNC5H4 |
| Short name: |
UNC5D/UNC5H4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, elegans)/UNC5H4 (Antibody to), unc-5 homolog D (C |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, UNC5D and IDBG-16693 and ENSG00000156687 and 137970, UNC5D and IDBG-628993 and ENSBTAG00000010241 and 520004, Unc5d and IDBG-146351 and ENSMUSG00000063626 and 210801, elegans), protein binding, this GO :0005515 and protein binding and molecular function this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0009986 and cell surface and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0021859 and pyramidal neuron differentiation and biological process this GO :2001222 and regulation of neuron migration and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, unc-5 homolog D (C |
| Identity: |
18634 |
| Gene: |
UNC5D |
More about : UNC5D |
| Long gene name: |
unc-5 netrin receptor D |
| Synonyms gene name: |
elegans) , unc-5 homolog D (C |
| Synonyms name: |
Netrin receptor UNC5D Protein unc-5 homolog 4 Protein unc-5 homolog D |
| Locus: |
8p12 |
| Discovery year: |
2002-05-13 |
| GenBank acession: |
AB055056 |
| Entrez gene record: |
137970 |
| Pubmed identfication: |
18402767 |
| Classification: |
I-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000157145 |