| Long name: |
FITC Conjugated, UNC5D/UNC5H4 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
UNC5D/UNC5H4 |
| Specificity: |
This is a highly specific antibody against UNC5D/UNC5H4 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Extracellular |
| Source: |
KLH conjugated synthetic peptide derived from human UNC5H4 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Additionally, In the absence of netrin-1, The expression of UNC5H receptors is down-regulated in multiple carcinomas, This activity is blocked by the binding of netrin-1, Two isoforms of UNC5H4 exist due to alternative splicing events, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, UNC5H4, also known as UNC5D (unc-5 homolog D), and kidney cancers, breast, but mutation of these receptors provides a potential mechanism for tumorigenicity, including colorectal, is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family, lung, ovary, stomach, uterus, when cleaved by a caspase to produce an intracellular fragment containing a death domain, The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells, UNC5H receptors induce apoptosis |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
KIAA1777 Unc5h4 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
UNC5D/UNC5H4 Conjugated |
| Short name: |
FITC Conjugated, UNC5D/UNC5H4 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
elegans)/UNC5H4 (Antibody to), fluorecein coupled, unc-5 homolog D (C |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, UNC5D and IDBG-16693 and ENSG00000156687 and 137970, UNC5D and IDBG-628993 and ENSBTAG00000010241 and 520004, Unc5d and IDBG-146351 and ENSMUSG00000063626 and 210801, elegans), protein binding, this GO :0005515 and protein binding and molecular function this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0009986 and cell surface and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0021859 and pyramidal neuron differentiation and biological process this GO :2001222 and regulation of neuron migration and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, unc-5 homolog D (C |
| Identity: |
18634 |
| Gene: |
UNC5D |
More about : UNC5D |
| Long gene name: |
unc-5 netrin receptor D |
| Synonyms gene name: |
elegans) , unc-5 homolog D (C |
| Synonyms name: |
Netrin receptor UNC5D Protein unc-5 homolog 4 Protein unc-5 homolog D |
| Locus: |
8p12 |
| Discovery year: |
2002-05-13 |
| GenBank acession: |
AB055056 |
| Entrez gene record: |
137970 |
| Pubmed identfication: |
18402767 |
| Classification: |
I-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000157145 |