| Long name: |
ALEXA FLUOR 647 Conjugated, Repulsive Guidance Molecule C Antibody |
| Also known as: |
Anti-RGMC/Repulsive Guidance Molecule C PAb ALEXA FLUOR 647 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
647, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
RGMC/Repulsive Guidance Molecule C |
| Specificity: |
This is a highly specific antibody against RGMC/Repulsive Guidance Molecule C |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Repulsive Guidance Molecule C |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Defects in the gene encoding for RGMc causes the autosomal recessive disorder juvenile hemochromatosis (JH), Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness, RGM have been implicated in both axonal guidance and neural tube closure but as opposed to for ephrins, RGMa and RGMb, RGMc, The RGM proteins are attached to the membrane by a GPI-anchor, They are repulsive for a group of axons, Two members of this family, also known as Hemojuvelin, are expressed in the nervous system, is a part of the signaling pathway activating hepcidin and works together with hepcidin to restrict iron absorption in the gut, netrins and slits, no receptor mechanism for RGM activation has been defined, semaphorins, those from the temporal half of the retina, The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
650nm/665nm |
| Synonyms: |
JH HFE2A RGMC HJV hemojuvelin haemojuvelin |
| Properties: |
ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the Repulsive Guidance Molecule C Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 647, Alexa Fluor |
| Description: |
present in lysates used as reference for ELISA quantification of these molecules and their subunits, Whole adhesion and interacting molecules are  |
| Gene target: |
Repulsive Guidance Molecule C |
| Short name: |
Repulsive Guidance Molecule C Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 647 |
| Alternative name: |
ALEXA FLUOR 647, Repulsive Guidance Molecule C (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
4887 |
| Gene: |
HFE2 |
More about : HFE2 |
| Long gene name: |
hemochromatosis type 2 (juvenile) |
| Synonyms name: |
repulsive guidance molecule c |
| Locus: |
1q21, 1 |
| Discovery year: |
1999-05-25 |
| GenBank acession: |
AY372521 |
| Entrez gene record: |
148738 |
| Pubmed identfication: |
10205270 14647275 |
| RefSeq identity: |
NM_145277 |
| Havana BLAST/BLAT: |
OTTHUMG00000013748 |