| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
RGMC/Repulsive Guidance Molecule C |
| Specificity: |
This antibody reacts specifically with Repulsive Guidance Molecule C |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Repulsive Guidance Molecule C |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Defects in the gene encoding for RGMc causes the autosomal recessive disorder juvenile hemochromatosis (JH), Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness, RGM have been implicated in both axonal guidance and neural tube closure but as opposed to for ephrins, RGMa and RGMb, RGMc, The RGM proteins are attached to the membrane by a GPI-anchor, They are repulsive for a group of axons, Two members of this family, also known as Hemojuvelin, are expressed in the nervous system, is a part of the signaling pathway activating hepcidin and works together with hepcidin to restrict iron absorption in the gut, netrins and slits, no receptor mechanism for RGM activation has been defined, semaphorins, those from the temporal half of the retina, The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
HEMOCHROMATOSIS, HEMOCHROMATOSIS, HEMOCHROMATOSIS, HEMOCHROMATOSIS DUE TO DEFECT IN HEMOJUVELIN, HEMOCHROMATOSIS DUE TO DEFECT IN HEPCIDIN ANTIMICROBIAL PEPTIDE, HEMOCHROMATOSIS JUVENILE, HFE 2, HFE2A, HJV, Haemojuvelin, Hemochromatosis type 2, Hemochromatosis type 2 juvenile, Hemochromatosis type 2 protein, Hemochromatosis type 2 protein homolog, Hemojuvelin, Hfe2, JH, Juvenile, MGC23953, RGM C, RGM domain family member C, RGMC, RGMC_HUMAN, Repulsive guidance molecule c, TYPE 2A, TYPE 2B, DL M |
| Also known as: |
Repulsive Guidance Molecule C Antibody |
| Other name: |
Anti-Repulsive Guidance Molecule C |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Description: |
present in lysates used as reference for ELISA quantification of these molecules and their subunits, Whole adhesion and interacting molecules are |
| Gene target: |
Repulsive Guidance Molecule C |
| Short name: |
Fluor 594, Anti-Repulsive Guidance Molecule C |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Repulsive Guidance Molecule C |