| Long name: |
FITC Conjugated, Microcephalin 1/BRIT1 Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Microcephalin 1/BRIT1 |
| Specificity: |
This is a highly specific antibody against Microcephalin 1/BRIT1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human Microcephalin 1/BRIT1 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Human Microcephalin contains three BRCA1 C-terminal (BRCT) domains and shares 57% identity with its mouse ortholog, It functions in DNA damage response and regulation of cell cycle checkpoints, Microcephalin displays significantly higher rates of protein evolution in primates than in rodents, Microcephalin has a very young, Predominant expression of human Microcephalin is observed in fetal brain, although the nature of the positive selection is poorly understood, liver and kidney tissues and is expressed during neurogenesis in mice, polymorphism haplotype associated with modern humans, single nucleotide, the most conserved regions being BRCT domains where there is 80% identity, this gene is presumably still evolving in Homo sapiens, this trend is most noticeable for the subset of genes associated with nervous system development, Microcephalin modulates brain size and has been proliferating under strong positive selection for several thousand years |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
FLJ12847 BRIT1 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Microcephalin 1/BRIT1 Conjugated |
| Short name: |
FITC Conjugated, Microcephalin 1/BRIT1 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, Microcephalin 1/BRIT1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6954 |
| Gene: |
MCPH1 |
More about : MCPH1 |
| Long gene name: |
microcephalin 1 |
| Synonyms gene name: |
microcephaly, primary autosomal recessive 1 |
| Synonyms name: |
BRCT-repeat inhibitor of TERT expression 1 |
| Locus: |
8p23, 1 |
| Discovery year: |
1998-02-11 |
| GenBank acession: |
AK022909 |
| Entrez gene record: |
79648 |
| Pubmed identfication: |
9683597 17925396 |
| RefSeq identity: |
NM_024596 |
| Havana BLAST/BLAT: |
OTTHUMG00000163618 |