| Catalog number: | bs-11227R-Cy3 |
|---|---|
| Price: | 350 € |
| Supplier: | Bioss Primary Conjugated Antibodies |
| Product name: | Microcephalin 1/BRIT1 Antibody, Cy3 Conjugated |
| Quantity: | 0.1ml |
| Related search: |
| Long name: | Cy3 Conjugated, Microcephalin 1/BRIT1 Antibody |
|---|---|
| Category: | Conjugated Primary Antibodies |
| Conjugation: | cy3 conjugation kit |
| Host Organism: | Rabbit (Oryctolagus cuniculus) |
| Target Antigen: | Microcephalin 1/BRIT1 |
| Specificity: | This is a highly specific antibody against Microcephalin 1/BRIT1 |
| Modification: | Unmodified |
| Modification site: | None |
| Clonality: | Polyclonal |
| Clone: | Polyclonal antibody |
| Concentration: | 1ug per 1ul |
| Source: | KLH conjugated synthetic peptide derived from human Microcephalin 1/BRIT1 |
| Tested applications: | IF(IHC-P) |
| Recommended dilutions: | IF(IHC-P)(1:50-200) |
| Crossreactivity: | Mouse, Human |
| Crossreactive species details: | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: | Human Microcephalin contains three BRCA1 C-terminal (BRCT) domains and shares 57% identity with its mouse ortholog, It functions in DNA damage response and regulation of cell cycle checkpoints, Microcephalin displays significantly higher rates of protein evolution in primates than in rodents, Microcephalin has a very young, Predominant expression of human Microcephalin is observed in fetal brain, although the nature of the positive selection is poorly understood, liver and kidney tissues and is expressed during neurogenesis in mice, polymorphism haplotype associated with modern humans, single nucleotide, the most conserved regions being BRCT domains where there is 80% identity, this gene is presumably still evolving in Homo sapiens, this trend is most noticeable for the subset of genes associated with nervous system development, Microcephalin modulates brain size and has been proliferating under strong positive selection for several thousand years |
| Purification method: | This antibody was purified via Protein A |
| Storage conditions: | 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: | 512, 550nm/570, 615nm |
| Synonyms: | FLJ12847 BRIT1 |
| Properties: | 1 of the Microcephalin 1/BRIT1 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: | Microcephalin 1/BRIT1 Conjugated |
| Short name: | Conjugated, Microcephalin 1/BRIT1 Antibody |
| Technique: | antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: | Cy3 |
| Alternative name: | cyanine 3 coupled, Microcephalin 1/BRIT1 (Antibody to) |
| Alternative technique: | antibodies |
| Identity: | 6954 |
| Gene: | MCPH1 | More about : MCPH1 |
| Long gene name: | microcephalin 1 |
| Synonyms gene name: | microcephaly, primary autosomal recessive 1 |
| Synonyms name: | BRCT-repeat inhibitor of TERT expression 1 |
| Locus: | 8p23, 1 |
| Discovery year: | 1998-02-11 |
| GenBank acession: | AK022909 |
| Entrez gene record: | 79648 |
| Pubmed identfication: | 9683597 17925396 |
| RefSeq identity: | NM_024596 |
| Havana BLAST/BLAT: | OTTHUMG00000163618 |
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