| Long name: |
HER4/ErbB4 Primary Polyclonal Antibody |
| Also known as: |
HER4/ErbB4 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
HER4/ErbB4 |
| Specificity: |
This is a highly specific antibody against HER4/ErbB4 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
460-510/1308 |
| Subcellular location: |
Extracellular |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human HER4/ErbB4 |
| Gene ID number: |
2066 |
| Swiss Prot: |
Q15303 |
| Tested Applications: |
IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as cell-surface receptor for the neuregulins NRG1, EREG and HBEGF, Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1, Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors, Ligand specificity and signaling is modulated by alternative splicing, Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1, NRG2, NRG3 and NRG4 and the EGF family members BTC, Required for mammary gland differentiation, Required for normal cardiac muscle differentiation during embryonic development, Required for normal development of the embryonic central nervous system, and by the formation of heterodimers with other ERBB family members, and do not promote reorganization of the actin cytoskeleton and cell migration, and for postnatal cardiomyocyte proliferation, and hence do not phosphorylate PIK3R1, cell proliferation, differentiation, do not protect cells against apoptosis, especially for normal neural crest cell migration and normal axon guidance, gene transcription, induction of milk proteins and lactation, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis, migration and apoptosis, proteolytic processing, the central nervous system and the mammary gland, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses, Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ALS19, ERBB4, Proto-oncogene-like protein c-ErbB-4, Receptor tyrosine-protein kinase erbB-4, Tyrosine kinase-type cell surface receptor HER4, p180erbB4, HER4 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
HER4/ErbB4 |
| Short name: |
HER4/ErbB4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
HER4/v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
3432 |
| Gene: |
ERBB4 |
More about : ERBB4 |
| Long gene name: |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms gene name: |
v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 |
| Synonyms: |
ALS19 HER4 |
| Synonyms name: |
human epidermal growth factor receptor 4 |
| Locus: |
2q34 |
| Discovery year: |
1995-09-07 |
| GenBank acession: |
L07868 |
| Entrez gene record: |
2066 |
| Pubmed identfication: |
7700649 17018285 |
| RefSeq identity: |
NM_001042599 |
| Classification: |
Erb-b2 receptor tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000133012 |