| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ERBB4 (HER4) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the ERBB4 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This ERBB4 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q15303 |
| Purity: |
Antigen affinity |
| Description: |
After binding its ligand, ERBB2 and ERBB3, ERBB4 is a single-pass type I transmembrane protein with multiplefurin-like cysteine rich domains, Itis a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation, Ni et al, The HER4/ERBB4 gene is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, a phosphotidylinositol-3 kinase binding site and aPDZ domainbinding motif, a tyrosine kinase domain, also known as HER4, heregulin, is an enzyme that in humans is encoded by the ERBB4 gene, or activation of protein kinase C by TPA, the ERBB4 ectodomain is cleaved by a metalloprotease, (2000) reported that the proteinis enriched in the postsynaptic density and associates with PSD95, (2001)concluded that gamma-secretase cleavage ofthe proteinmay represent another mechanism for receptor tyrosine kinase-mediated signaling, Huang et al, V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 |
| Immunogen: |
mouse and rat), An amino acid sequence from the N-terminus of human ErbB4/HER4 (KLSSLSDLEQQYRALRK) was used as the immunogen for this ERBB4 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the ERBB4 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ERBB4 (HER4) |
| Short name: |
ERBB4 Antibody (HER4) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (Antibody to) (HER4) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ALS19 and HER4 and p180erbB4, DNA-templated and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007399 and nervous system development and biological process this GO :0007507 and heart development and biological process this GO :0007595 and lactation and biological process this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009880 and embryonic pattern specification and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016323 and basolateral plasma membrane and cellular component this GO :0016477 and cell migration and biological process this GO :0016772 and transferase activity, DNA-templated and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0060045 and positive regulation of cardiac muscle cell proliferation and biological process this GO :0060644 and mammary gland epithelial cell differentiation and biological process this GO :0060749 and mammary gland alveolus development and biological process this GO :0061026 and cardiac muscle tissue regeneration and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :2000366 and positive regulation of STAT protein import into nucleus and biological process, ERBB4 and IDBG-643612 and ENSBTAG00000012647 and, ERBB4 and IDBG-79992 and ENSG00000178568 and 2066, Erbb4 and IDBG-164078 and ENSMUSG00000062209 and 13869, nuclei, this GO :0001755 and neural crest cell migration and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0004716 and receptor signaling protein tyrosine kinase activity and molecular function this GO :0005154 and epidermal growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005759 and mitochondrial matrix and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006351 and transcription, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0004716 : receptor signaling protein tyrosine kinase activity and also this GO :0005154 : epidermal growth factor receptor binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0004716 : receptor signaling protein tyrosine kinase activity, this GO :0005154 : epidermal growth factor receptor binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0042803 : protein homodimerization activity, this GO :0044212 : transcription regulatory region DNA binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0042803 : protein homodimerization activity and also this GO :0044212 : transcription regulatory region DNA binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0021551 and central nervous system morphogenesis and biological process this GO :0021889 and olfactory bulb interneuron differentiation and biological process this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030334 and regulation of cell migration and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042523 and positive regulation of tyrosine phosphorylation of Stat5 protein and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043235 and receptor complex and cellular component this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0043653 and mitochondrial fragmentation involved in apoptotic process and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045165 and cell fate commitment and biological process this GO :0045893 and positive regulation of transcription, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) |
| Identity: |
3432 |
| Gene: |
ERBB4 |
More about : ERBB4 |
| Long gene name: |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms gene name: |
v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 |
| Synonyms: |
ALS19 HER4 |
| Synonyms name: |
human epidermal growth factor receptor 4 |
| Locus: |
2q34 |
| Discovery year: |
1995-09-07 |
| GenBank acession: |
L07868 |
| Entrez gene record: |
2066 |
| Pubmed identfication: |
7700649 17018285 |
| RefSeq identity: |
NM_001042599 |
| Classification: |
Erb-b2 receptor tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000133012 |