| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ERBB4 (HER4) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:500 |
| Notes: |
Titration of the ERBB4 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This ERBB4 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q15303 |
| Purity: |
Antigen affinity |
| Description: |
Acts as cell-surface receptor for the neuregulins NRG1, EREG and HBEGF, Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1, Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors, Ligand specificity and signaling is modulated by alternative splicing, Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1, NRG2, NRG3 and NRG4 and the EGF family members BTC, Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, Required for mammary gland differentiation, Required for normal cardiac muscle differentiation during embryonic development, Required for normal development of the embryonic central nervous system, The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation, The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis, [UniProt], activation of STAT5A, and by the formation of heterodimers with other ERBB family members, and do not promote reorganization of the actin cytoskeleton and cell migration, and for postnatal cardiomyocyte proliferation, and hence do not phosphorylate PIK3R1, cell proliferation, cell proliferation and activation of gene expression, differentiation, do not protect cells against apoptosis, especially for normal neural crest cell migration and normal axon guidance, gene transcription, induction of milk proteins and lactation, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis, mammary epithelium differentiation, migration and apoptosis, promote nuclear import of STAT5A, proteolytic processing, the central nervous system and the mammary gland, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses, Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart |
| Immunogen: |
This ERBB4 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1165-1199 amino acids from the C-terminal region of human ERBB4 |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the ERBB4 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ERBB4 (HER4) |
| Short name: |
ERBB4 Antibody (HER4) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (Antibody to) (HER4) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ALS19 and HER4 and p180erbB4, DNA-templated and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0007165 and signal transduction and biological process this GO :0007169 and transmembrane receptor protein tyrosine kinase signaling pathway and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007399 and nervous system development and biological process this GO :0007507 and heart development and biological process this GO :0007595 and lactation and biological process this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009880 and embryonic pattern specification and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016323 and basolateral plasma membrane and cellular component this GO :0016477 and cell migration and biological process this GO :0016772 and transferase activity, DNA-templated and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0060045 and positive regulation of cardiac muscle cell proliferation and biological process this GO :0060644 and mammary gland epithelial cell differentiation and biological process this GO :0060749 and mammary gland alveolus development and biological process this GO :0061026 and cardiac muscle tissue regeneration and biological process this GO :0070374 and positive regulation of ERK1 and ERK2 cascade and biological process this GO :2000366 and positive regulation of STAT protein import into nucleus and biological process, ERBB4 and IDBG-643612 and ENSBTAG00000012647 and, ERBB4 and IDBG-79992 and ENSG00000178568 and 2066, Erbb4 and IDBG-164078 and ENSMUSG00000062209 and 13869, nuclei, this GO :0001755 and neural crest cell migration and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004714 and transmembrane receptor protein tyrosine kinase activity and molecular function this GO :0004716 and receptor signaling protein tyrosine kinase activity and molecular function this GO :0005154 and epidermal growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005759 and mitochondrial matrix and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006351 and transcription, this GO :0004672 : protein kinase activity, this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004714 : transmembrane receptor protein tyrosine kinase activity and also this GO :0004716 : receptor signaling protein tyrosine kinase activity and also this GO :0005154 : epidermal growth factor receptor binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004714 : transmembrane receptor protein tyrosine kinase activity, this GO :0004716 : receptor signaling protein tyrosine kinase activity, this GO :0005154 : epidermal growth factor receptor binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0042803 : protein homodimerization activity, this GO :0044212 : transcription regulatory region DNA binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0042803 : protein homodimerization activity and also this GO :0044212 : transcription regulatory region DNA binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0021551 and central nervous system morphogenesis and biological process this GO :0021889 and olfactory bulb interneuron differentiation and biological process this GO :0023014 and signal transduction by phosphorylation and biological process this GO :0030334 and regulation of cell migration and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042523 and positive regulation of tyrosine phosphorylation of Stat5 protein and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043235 and receptor complex and cellular component this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0043653 and mitochondrial fragmentation involved in apoptotic process and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045165 and cell fate commitment and biological process this GO :0045893 and positive regulation of transcription, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) |
| Identity: |
3432 |
| Gene: |
ERBB4 |
More about : ERBB4 |
| Long gene name: |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms gene name: |
v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 |
| Synonyms: |
ALS19 HER4 |
| Synonyms name: |
human epidermal growth factor receptor 4 |
| Locus: |
2q34 |
| Discovery year: |
1995-09-07 |
| GenBank acession: |
L07868 |
| Entrez gene record: |
2066 |
| Pubmed identfication: |
7700649 17018285 |
| RefSeq identity: |
NM_001042599 |
| Classification: |
Erb-b2 receptor tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000133012 |