| Long name: |
Smad7 + Smad6 Primary Polyclonal Antibody |
| Also known as: |
Smad7 + Smad6 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Smad7 + Smad6 |
| Specificity: |
This is a highly specific antibody against Smad7 + Smad6 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
1-50/426 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Smad7 |
| Gene ID number: |
4092 |
| Swiss Prot: |
O15105 |
| Tested Applications: |
ELISA, IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
ELISA(1:500-1000), IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex, Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity), has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access, which promotes its dephosphorylation, Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
MAD homolog 7, MAD homolog 8, MADH7, MADH8, Mothers against DPP homolog 7, Mothers against DPP homolog 8, Mothers against decapentaplegic homolog 7, Mothers against decapentaplegic homolog 8, SMAD 7, SMAD family member 7, Smad7, hSMAD7, CRCS3 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Smad7 + Smad6 |
| Short name: |
Smad7 + Smad6 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SMAD family member 7 and SMAD family member 6 (Antibody to) |
| Alternative technique: |
antibodies |