| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SMAD6 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Mouse (Mus musculus) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the SMAD6 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This SMAD6 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O43541 |
| Purity: |
Antigen affinity |
| Description: |
Multiple transcript variants encoding different isoforms have been found for this gene, SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways, This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling, elegans Sma, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C, The protein encoded by this gene belongs to the SMAD family of proteins |
| Immunogen: |
A portion of amino acids 357-386 from the human protein was used as the immunogen for this SMAD6 antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the SMAD6 antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SMAD6 |
| Short name: |
SMAD6 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SMAD family member 6 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AOVD2 and HsT17432 and MADH6 and MADH7, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006955 and immune response and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007352 and zy this GO tic specification of dorsal/ventral axis and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0010991 and negative regulation of SMAD protein complex assembly and biological process this GO :0030509 and BMP signaling pathway and biological process this GO :0030512 and negative regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0030514 and negative regulation of BMP signaling pathway and biological process this GO :0030617 and transforming growth factor beta receptor, SMAD6 and IDBG-18304 and ENSG00000137834 and 4091, SMAD6 and IDBG-645465 and ENSBTAG00000000625 and 511279, Smad6 and IDBG-175757 and ENSMUSG00000036867 and 17130, inhibitory cytoplasmic mediator activity, inhibitory cytoplasmic mediator activity and also this GO :0031625 : ubiquitin protein ligase binding and also this GO :0034713 : type I transforming growth factor beta receptor binding and also this GO :0044212 : transcription regulatory region DNA binding and also this GO :0046872 : metal ion binding and also this GO :0070410 : co-SMAD binding and also this GO :0070411 : I-SMAD binding and also this GO :0070412 : R-SMAD binding and also this GO :0070698 : type I activin receptor binding, inhibitory cytoplasmic mediator activity and molecular function this GO :0031589 and cell-substrate adhesion and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0034616 and response to laminar fluid shear stress and biological process this GO :0034713 and type I transforming growth factor beta receptor binding and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043234 and protein complex and cellular component this GO :0043627 and response to estrogen and biological process this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045444 and fat cell differentiation and biological process this GO :0046872 and metal ion binding and molecular function this GO :0060394 and negative regulation of pathway-restricted SMAD protein phosphorylation and biological process this GO :0070410 and co-SMAD binding and molecular function this GO :0070411 and I-SMAD binding and molecular function this GO :0070412 and R-SMAD binding and molecular function this GO :0070698 and type I activin receptor binding and molecular function, nuclei, this GO :0001657 and ureteric bud development and biological process this GO :0003682 and chromatin binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0003682 : chromatin binding, this GO :0003682 : chromatin binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0005515 : protein binding and also this GO :0030617 : transforming growth factor beta receptor, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0005515 : protein binding, this GO :0030617 : transforming growth factor beta receptor, this GO :0031625 : ubiquitin protein ligase binding, this GO :0034713 : type I transforming growth factor beta receptor binding, this GO :0044212 : transcription regulatory region DNA binding, this GO :0046872 : metal ion binding, this GO :0070410 : co-SMAD binding, this GO :0070411 : I-SMAD binding, this GO :0070412 : R-SMAD binding, this GO :0070698 : type I activin receptor binding, transforming growth factor beta receptor, SMAD family member 6 |
| Identity: |
6772 |
| Gene: |
SMAD6 |
More about : SMAD6 |
| Long gene name: |
SMAD family member 6 |
| Synonyms gene: |
MADH7 MADH6 |
| Synonyms gene name: |
MAD, mothers against DPP homolog 6 (Drosophila) , mothers against decapentaplegic homolog 6 (Drosophila) SMAD |
| Synonyms: |
HsT17432 |
| Locus: |
15q22, 31 |
| Discovery year: |
1997-08-22 |
| GenBank acession: |
BC012986 |
| Entrez gene record: |
4091 |
| Pubmed identfication: |
9256479 |
| RefSeq identity: |
NM_005585 |
| Classification: |
SMAD family |
| Havana BLAST/BLAT: |
OTTHUMG00000133218 |
| Locus Specific Databases: |
The Globin Gene Server |