| Long name: |
HRP Conjugated, p19ARF Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
HRP Conjugated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
p19ARF |
| Specificity: |
This is a highly specific antibody against p19ARF |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human P19ARF |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Rat, Mouse |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Acts as a tumor suppressor, Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes, Binds to BCL6 and down-regulates BCL6-induced transcriptional repression, Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression, Binds to HUWE1 and represses its ubiquitin ligase activity, Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus, Binds to TOP1/TOPOI and stimulates its activity, Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1, May play a role in controlling cell proliferation and apoptosis during mammary gland development, This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation, This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis, thus inhibiting rRNA processing, P19ARF Capable of inducing cell cycle arrest in G1 and G2 phases |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% Gentamicin, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
Cdkn2a, isoform 2, p19ARF, Cyclin-dependent kinase inhibitor 2A |
| Properties: |
Also monoclonal HRP conjugates are often used for Western Blot, HRP conjugates are often primary rabbit polyclonal antibodies couples to the , found in the roots of , (HRP), C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°, enzyme , horseradish, horseradish peroxidase |
| Gene target: |
p19ARF Conjugated |
| Short name: |
Conjugated, p19ARF Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
HRP |
| Alternative name: |
horseradish peroxidase coupled, p19ARF (Antibody to) |
| Alternative technique: |
antibodies |