p19ARF Antibody

Catalog number:	bs-0534R Buy Now
Price:	602 €
Supplier:	genways
Product name:	p19ARF Antibody
Quantity:	1 x 1 vial
Related search:	parf antibody gene this synonyms cyclin

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Long name:	p19ARF Primary Polyclonal Antibody
Also known as:	p19ARF PAb
Category:	Primary Antibodies
Conjugation:	Unconjugated
Target Antigen:	p19ARF
Specificity:	This is a highly specific antibody against p19ARF
Modification(s):	None
Modification site(s):	Unmodified antibody
Clonality:	Polyclonal antibody
Clone number:	Polyclonal antibody
Concentration:	1ug per 1ul
Source:	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human P19ARF
Tested Applications:	IF(IHC-P), IHC-P, WB
Recommended dilutions:	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity:	Rat, Mouse
Cross reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen:	Acts as a tumor suppressor, Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes, Binds to BCL6 and down-regulates BCL6-induced transcriptional repression, Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression, Binds to HUWE1 and represses its ubiquitin ligase activity, Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus, Binds to TOP1/TOPOI and stimulates its activity, Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1, May play a role in controlling cell proliferation and apoptosis during mammary gland development, This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation, This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis, thus inhibiting rRNA processing, P19ARF Capable of inducing cell cycle arrest in G1 and G2 phases
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names:	Cdkn2a, isoform 2, p19ARF, Cyclin-dependent kinase inhibitor 2A
Properties:	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target:	p19ARF
Short name:	p19ARF Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Alternative name:	p19ARF (Antibody to)
Alternative technique:	antibodies
Identity:	1787
Gene:	CDKN2A | More about : CDKN2A
Long gene name:	cyclin dependent kinase inhibitor 2A
Synonyms gene:	CDKN2 MLM
Synonyms gene name:	cyclin-dependent kinase inhibitor 2A (melanoma, inhibits CDK4) , p16
Synonyms:	CDK4I p16 INK4a MTS1 CMM2 ARF p19 p14 INK4 p16INK4a p19Arf p14ARF
Locus:	9p21, 3
Discovery year:	1994-05-19
GenBank acession:	L27211
Entrez gene record:	1029
Pubmed identfication:	8152487 7606716
RefSeq identity:	NM_000077
Havana BLAST/BLAT:	OTTHUMG00000019686
Locus Specific Databases:	LOVD - Leiden Open Variation Database LRG_11

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