| Long name: |
ALEXA FLUOR 555 Conjugated, p19ARF Polyclonal Antibody |
| Also known as: |
Anti-p19ARF PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
p19ARF |
| Specificity: |
This is a highly specific antibody against p19ARF |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human P19ARF |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Rat, Mouse |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts as a tumor suppressor, Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes, Binds to BCL6 and down-regulates BCL6-induced transcriptional repression, Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression, Binds to HUWE1 and represses its ubiquitin ligase activity, Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus, Binds to TOP1/TOPOI and stimulates its activity, Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1, May play a role in controlling cell proliferation and apoptosis during mammary gland development, This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation, This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis, thus inhibiting rRNA processing, P19ARF Capable of inducing cell cycle arrest in G1 and G2 phases |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
CDK4I p16 INK4a MTS1 CMM2 ARF p19 p14 INK4 p16INK4a p19Arf p14ARF |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
p19ARF |
| Short name: |
p19ARF Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, p19ARF (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1787 |
| Gene: |
CDKN2A |
More about : CDKN2A |
| Long gene name: |
cyclin dependent kinase inhibitor 2A |
| Synonyms gene: |
CDKN2 MLM |
| Synonyms gene name: |
cyclin-dependent kinase inhibitor 2A (melanoma, inhibits CDK4) , p16 |
| Locus: |
9p21, 3 |
| Discovery year: |
1994-05-19 |
| GenBank acession: |
L27211 |
| Entrez gene record: |
1029 |
| Pubmed identfication: |
8152487 7606716 |
| RefSeq identity: |
NM_000077 |
| Havana BLAST/BLAT: |
OTTHUMG00000019686 |
| Locus Specific Databases: |
LOVD - Leiden Open Variation Database LRG_11 |