| Category: |
Antibody |
| Concentration: |
pH 7, with 0, 09% sodium azide, 4, In 1X PBS |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
GPNMB |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
ELISA, WB |
| Recommended dilutions: |
Western blot: 1:1000 |
| Notes: |
Titration of the GPNMB antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This GPNMB antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q14956 |
| Purity: |
Antigen affinity |
| Description: |
GPNMB may be involved in growth delay and reduction of metastatic potential, GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines, Two transcript variants encoding different isoforms have been found for this gene, a melanocyte-specific protein, The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor |
| Immunogen: |
A portion of amino acids 541-569 from the human protein was used as the immunogen for this GPNMB antibody |
| Storage: |
Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the GPNMB antibody and store frozen at -20 deg |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
GPNMB |
| Short name: |
GPNMB Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
glycoprotein (transmembrane) nmb (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, GPNMB and IDBG-9627 and ENSG00000136235 and 10457, Gpnmb and IDBG-146080 and ENSMUSG00000029816 and 93695, HGFIN and NMB, Plasma membranes, heparin binding, this GO :0001649 and osteoblast differentiation and biological process this GO :0005178 and integrin binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007155 and cell adhesion and biological process this GO :0008201 and heparin binding and molecular function this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016023 and cytoplasmic membrane-bounded vesicle and cellular component this GO :0030282 and bone mineralization and biological process this GO :0042470 and melanosome and cellular component, this GO :0005178 : integrin binding, this GO :0005178 : integrin binding and also this GO :0008201 : heparin binding, this GO :0008201 : heparin binding, 99652 and IDBG-630320 and ENSBTAG00000000604 and 509600, glycoprotein (transmembrane) nmb |
| Identity: |
4462 |
| Gene: |
GPNMB |
More about : GPNMB |
| Long gene name: |
glycoprotein nmb |
| Synonyms gene name: |
glycoprotein (transmembrane) nmb |
| Synonyms: |
NMB HGFIN |
| Synonyms name: |
transmembrane glycoprotein glycoprotein NMB glycoprotein nmb-like protein osteoactivin hematopoietic growth factor inducible neurokinin-1 glycoprotein nonmetastatic melanoma protein B |
| Locus: |
7p15, 3 |
| Discovery year: |
1999-10-26 |
| GenBank acession: |
X76534 |
| Entrez gene record: |
10457 |
| Pubmed identfication: |
7814155 |
| RefSeq identity: |
NM_001005340 |
| Havana BLAST/BLAT: |
OTTHUMG00000022811 |