| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
OSTM1 |
| Specificity: |
This antibody reacts specifically with OSTM1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human OSTM1 |
| Gene ID: |
28962 |
| Swiss Prot: |
Q86WC4 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
ARO is suggested to be caused by mutations in the OSTM1 gene, Bone autosomal recessive osteopetrosis (ARO) is the most severe form of hereditary bone disease whose cellular basis is in the osteoclast and is characterized by abnormally dense bone, Defects in the OSTM1 gene are also the cause of the spontaneous gl mutant, The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, also known as gl (gray-lethal) or HSPC019, and a benign autosomal dominant form occurring in adolescence or adulthood, due to defective resorption of immature bone, infancy, is a 338 amino acid single-pass type I membrane protein that is expressed primarily in osteoclasts and melanocytes as well as brain, kidney and spleen, or childhood, which is responsible for a coat color defect in mice, OSTM1 (osteopetrosis associated transmembrane protein 1) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
HSPC019 GL |
| Also known as: |
OSTM1 Polyclonal Antibody |
| Other name: |
Anti-OSTM1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
OSTM1 |
| Short name: |
Anti-OSTM1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-OSTM1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
21652 |
| Gene: |
OSTM1 |
More about : OSTM1 |
| Long gene name: |
osteopetrosis associated transmembrane protein 1 |
| Synonyms name: |
CLCN7 accessory beta subunit |
| Locus: |
6q21 |
| Discovery year: |
2003-10-06 |
| GenBank acession: |
AF533891 |
| Entrez gene record: |
28962 |
| Pubmed identfication: |
12627228 21527911 |
| RefSeq identity: |
NM_014028 |
| Havana BLAST/BLAT: |
OTTHUMG00000015317 |