| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
OSBP2 |
| Specificity: |
This antibody reacts specifically with OSBP2 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human OSBP2 |
| Gene ID: |
23762 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
HMG-CoA reductase and the low density lipoprotein receptor (LDLR), OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), OSBP localizes to the cytosol and is widely expressed, OSBPs are involved in lipid metabolism and signal transduction, The OSBP protein transports sterols from lysosomes to the nucleus, The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties, a suppressor of cholesterol synthesis gene transcription in cultured cells, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols, as well as vesicle transport, retina and fetal liver, where sterols downregulate the genes for HMG synthetase, which share a high overall similarity, while OSBP2 is mainly detected in testis, The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
KIAA1664 ORP-4 ORP4 |
| Also known as: |
OSBP2 Polyclonal Antibody |
| Other name: |
Anti-OSBP2 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
OSBP2 |
| Short name: |
Anti-OSBP2 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-OSBP2 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
8504 |
| Gene: |
OSBP2 |
More about : OSBP2 |
| Long gene name: |
oxysterol binding protein 2 |
| Synonyms gene: |
OSBPL1 |
| Locus: |
22q12, 2 |
| Discovery year: |
1999-10-29 |
| Entrez gene record: |
23762 |
| Pubmed identfication: |
10591208 11278871 11802775 |
| RefSeq identity: |
NM_030758 |
| Classification: |
Pleckstrin homology domain containing Oxysterol binding proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000151153 |