| Long name: |
FITC Conjugated, OSBP2 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
OSBP2 |
| Specificity: |
This is a highly specific antibody against OSBP2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human OSBP2 |
| Gene ID number: |
23762 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
HMG-CoA reductase and the low density lipoprotein receptor (LDLR), OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), OSBP localizes to the cytosol and is widely expressed, OSBPs are involved in lipid metabolism and signal transduction, The OSBP protein transports sterols from lysosomes to the nucleus, The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties, a suppressor of cholesterol synthesis gene transcription in cultured cells, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols, as well as vesicle transport, retina and fetal liver, where sterols downregulate the genes for HMG synthetase, which share a high overall similarity, while OSBP2 is mainly detected in testis, The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
KIAA1664 ORP-4 ORP4 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
OSBP2 Conjugated |
| Short name: |
FITC Conjugated, OSBP2 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, OSBP2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8504 |
| Gene: |
OSBP2 |
More about : OSBP2 |
| Long gene name: |
oxysterol binding protein 2 |
| Synonyms gene: |
OSBPL1 |
| Locus: |
22q12, 2 |
| Discovery year: |
1999-10-29 |
| Entrez gene record: |
23762 |
| Pubmed identfication: |
10591208 11278871 11802775 |
| RefSeq identity: |
NM_030758 |
| Classification: |
Pleckstrin homology domain containing Oxysterol binding proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000151153 |