| Long name: |
OSBP2 Primary Polyclonal Antibody |
| Also known as: |
OSBP2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
OSBP2 |
| Specificity: |
This is a highly specific antibody against OSBP2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human OSBP2 |
| Gene ID number: |
23762 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
HMG-CoA reductase and the low density lipoprotein receptor (LDLR), OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), OSBP localizes to the cytosol and is widely expressed, OSBPs are involved in lipid metabolism and signal transduction, The OSBP protein transports sterols from lysosomes to the nucleus, The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties, a suppressor of cholesterol synthesis gene transcription in cultured cells, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols, as well as vesicle transport, retina and fetal liver, where sterols downregulate the genes for HMG synthetase, which share a high overall similarity, while OSBP2 is mainly detected in testis, The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ORP4, OSBLP4, OSBP-related protein 4, OSBP2, OSBP2_HUMAN, OSBPL1, OSBPL4, Oxysterol Binding Protein 2, Oxysterol Binding Protein-like 1, oxysterol binding protein-related protein 4, ORP 4 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
OSBP2 |
| Short name: |
OSBP2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
OSBP2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8504 |
| Gene: |
OSBP2 |
More about : OSBP2 |
| Long gene name: |
oxysterol binding protein 2 |
| Synonyms gene: |
OSBPL1 |
| Synonyms: |
KIAA1664 ORP-4 ORP4 |
| Locus: |
22q12, 2 |
| Discovery year: |
1999-10-29 |
| Entrez gene record: |
23762 |
| Pubmed identfication: |
10591208 11278871 11802775 |
| RefSeq identity: |
NM_030758 |
| Classification: |
Pleckstrin homology domain containing Oxysterol binding proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000151153 |