| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
IGF-I Receptor beta |
| Specificity: |
This antibody reacts specifically with IGF-I Receptor beta |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human IGF-IR beta chain |
| Gene ID: |
3480 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Cleavage of the precursor generates alpha and beta subunits, It has tyrosine kinase activity, It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival, Jul 2008], The insulin-like growth factor I receptor plays a critical role in transformation events, [provided by RefSeq, This receptor binds insulin-like growth factor with a high affinity |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ALK-5 ACVRLK4 ALK5 |
| Also known as: |
IGF-I Receptor beta Polyclonal Antibody |
| Other name: |
Anti-IGF-I Receptor beta Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Description: |
IGF-1 acts via specific receptor, IGF-1R, IGF-II, Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver, Raf/Ras and PI3K cascades, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells, IGF-I |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
I Receptor beta |
| Short name: |
Anti-IGF-I Receptor beta (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , igfs, whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-IGF-I Receptor b (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
11772 |
| Gene: |
TGFBR1 |
More about : TGFBR1 |
| Long gene name: |
transforming growth factor beta receptor 1 |
| Synonyms gene: |
MSSE ESS1 |
| Synonyms gene name: |
multiple self-healing squamous epithelioma transforming growth factor beta receptor I |
| Synonyms name: |
53kDa , activin A receptor type II-like kinase |
| Locus: |
9q22, 33 |
| Discovery year: |
1993-09-30 |
| Entrez gene record: |
7046 |
| Pubmed identfication: |
1319842 8530052 21358634 |
| Classification: |
Type 1 receptor serine/threonine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000020353 |
| Locus Specific Databases: |
Belgium , Ghent, LOVD - Center for Medical Genetics |