| Long name: |
IGF-I Receptor beta Primary Polyclonal Antibody |
| Also known as: |
IGF-I Receptor beta PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
IGF-I Receptor beta |
| Specificity: |
This is a highly specific antibody against IGF-I Receptor beta |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human IGF-IR beta chain |
| Gene ID number: |
3480 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Cleavage of the precursor generates alpha and beta subunits, It has tyrosine kinase activity, It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival, Jul 2008], The insulin-like growth factor I receptor plays a critical role in transformation events, [provided by RefSeq, This receptor binds insulin-like growth factor with a high affinity |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CD221, CD221 antigen, IGF 1 receptor, IGF 1R, IGF I receptor, IGF I receptor beta, IGF1 Receptor, IGF1R, IGF1R beta, IGF1R_HUMAN, IGFIR, IGFIR beta, IGFIRC, Insulin like growth factor 1 receptor, Insulin like growth factor 1 receptor beta, Insulin like growth factor 1 receptor precursor, JTK13, MGC142170, MGC142172, GF 1R beta |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Description: |
IGF-1 acts via specific receptor, IGF-1R, IGF-II, Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver, Raf/Ras and PI3K cascades, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells, IGF-I |
| Gene target: |
I Receptor beta |
| Short name: |
IGF-I Receptor beta Antibody |
| Technique: |
antibodies against human proteins, antibodies for, igfs, Antibody |
| Alternative name: |
IGF-I Receptor b (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11772 |
| Gene: |
TGFBR1 |
More about : TGFBR1 |
| Long gene name: |
transforming growth factor beta receptor 1 |
| Synonyms gene: |
MSSE ESS1 |
| Synonyms gene name: |
multiple self-healing squamous epithelioma transforming growth factor beta receptor I |
| Synonyms: |
ALK-5 ACVRLK4 ALK5 |
| Synonyms name: |
53kDa , activin A receptor type II-like kinase |
| Locus: |
9q22, 33 |
| Discovery year: |
1993-09-30 |
| Entrez gene record: |
7046 |
| Pubmed identfication: |
1319842 8530052 21358634 |
| Classification: |
Type 1 receptor serine/threonine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000020353 |
| Locus Specific Databases: |
Belgium , Ghent, LOVD - Center for Medical Genetics |