| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MO25 alpha/CAB39 |
| Specificity: |
This antibody reacts specifically with MO25 alpha/CAB39 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MO25 alpha/CAB39 |
| Gene ID: |
51719 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
CAB39 binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, CAB39) is a 40-kDa protein that, LKB1-STRAD-MO25 activity is not increased by muscle contraction, Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase (AMPKK), The LKB1-STE-related adaptor (STRAD)-mouse protein 25 (MO25) complex is the major AMPKK in skeletal muscle, The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS), This relationship suggests that phosphorylation of AMPK by LKB1-STRAD-MO25 during skeletal muscle contraction may be regulated by allosteric mechanisms, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase, however, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, Mouse protein 25 alpha (MO25 alpha |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
CGI-66 MO25 |
| Also known as: |
MO25 alpha/CAB39 Polyclonal Antibody |
| Other name: |
Anti-MO25 alpha/CAB39 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MO25 alpha/CAB39 |
| Short name: |
Anti-MO25 alpha/CAB39 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-MO25 a/CAB39 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
20292 |
| Gene: |
CAB39 |
More about : CAB39 |
| Long gene name: |
calcium binding protein 39 |
| Locus: |
2q37, 1 |
| Discovery year: |
2004-07-02 |
| GenBank acession: |
AF113536 |
| Entrez gene record: |
51719 |
| RefSeq identity: |
NM_016289 |
| Havana BLAST/BLAT: |
OTTHUMG00000133220 |