| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
RSK3 |
| Specificity: |
This antibody reacts specifically with RSK3 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human RSK3/Ribosomal S6 kinase 3 |
| Gene ID: |
6196 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB, Rsk2 and Rsk3, Rsk3 is a distinct isoform of p90Rsk that translocates to the cell nucleus, Ser363 and Thr573, Several sites, These are broadly expressed serine/threonine protein kinases that are activated in response to mitogenic stimuli, Thr359, are important for its activation, including extracellular signal-regulated protein kinases Erk1 and Erk2, phosphorylates potential nuclear targets and may have a unique upstream activator, such as Ser380, which includes Rsk1, RSK3(Ribosomal S6 kinase 3)is a member of a family of 90-kDa ribosomal protein S6 kinases |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
RSK RSK3 HU-2 |
| Also known as: |
RSK3 Polyclonal Antibody |
| Other name: |
Anti-RSK3 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
RSK3 |
| Short name: |
Anti-RSK3 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-RSK3 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
10431 |
| Gene: |
RPS6KA2 |
More about : RPS6KA2 |
| Long gene name: |
ribosomal protein S6 kinase A2 |
| Synonyms gene name: |
90kD, polypeptide 2 , ribosomal protein S6 kinase |
| Locus: |
6q27 |
| Discovery year: |
1994-07-11 |
| GenBank acession: |
L07598 |
| Entrez gene record: |
6196 |
| Pubmed identfication: |
8141249 |
| RefSeq identity: |
NM_021135 |
| Classification: |
Mitogen-activated protein kinase-activated protein kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000016007 |