| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
TORC2 Ser171 |
| Specificity: |
This antibody reacts specifically with TORC2 (Ser171) |
| Modification: |
Phosphorylation |
| Modification site: |
Ser171 |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus |
| Antigen Source: |
KLH conjugated synthetic phosphopeptide derived from human CREB regulated transcription coactivator 2 around the phosphorylation site of Ser171 |
| Gene ID: |
200186 |
| Swiss Prot: |
Q53ET0 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as a coactivator, Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR), Enhances the interaction of CREB1 with TAF4, Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells, Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway, Regulates the expression of specific genes such as the steroidogenic gene, StAR, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation, in the SIK/TORC signaling pathway, Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
TORC2 |
| Also known as: |
TORC2 (Ser171) Polyclonal Antibody |
| Other name: |
Anti-TORC2 (Ser171) Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
TORC2 (Ser171) |
| Short name: |
Anti-TORC2 (Ser171) (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-TORC2 (Ser171) (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
27301 |
| Gene: |
CRTC2 |
More about : CRTC2 |
| Long gene name: |
CREB regulated transcription coactivator 2 |
| Locus: |
1q21, 3 |
| Discovery year: |
2005-11-24 |
| GenBank acession: |
AY360172 |
| Entrez gene record: |
200186 |
| Pubmed identfication: |
14506290 14536081 |
| RefSeq identity: |
NM_181715 |
| Havana BLAST/BLAT: |
OTTHUMG00000037156 |