| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
MEK6 |
| Specificity: |
This antibody reacts specifically with MEK6 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Nucleus, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human MEK6 |
| Gene ID: |
5608 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts also as a regulator for melanocytes dendricity, Especially, Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, MAP2K6/MKK6 also phosphorylates and activates PAK6, MAP2K6/MKK6 mediates apoptotic cell death in thymocytes, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses, Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1, The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors, The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction, With MAP3K3/MKK3, Within the p38 MAPK signal transduction pathway, and for IFNG-dependent gene transcription, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, through the modulation of Rho family GTPases, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF, Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
MEK6 MKK6 SAPKK3 MAPKK6 |
| Also known as: |
MEK6 Polyclonal Antibody |
| Other name: |
Anti-MEK6 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
MEK6 |
| Short name: |
Anti-MEK6 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-MEK6 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
6846 |
| Gene: |
MAP2K6 |
More about : MAP2K6 |
| Long gene name: |
mitogen-activated protein kinase kinase 6 |
| Synonyms gene: |
PRKMK6 |
| Synonyms name: |
kinase 6 (MAP kinase kinase 6) , mitogen-activated, protein kinase |
| Locus: |
17q24, 3 |
| Discovery year: |
1997-11-11 |
| GenBank acession: |
U39064 |
| Entrez gene record: |
5608 |
| Pubmed identfication: |
8621675 |
| RefSeq identity: |
NM_002758 |
| Classification: |
Mitogen-activated protein kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000180311 |