| Long name: |
MEK6 (MAP kinase kinase 6) (AF8B6) Monoclonal Antibody |
| Also known as: |
MEK6 (MAP kinase kinase 6) (AF8B6) Monoclonal Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
MEK6 (MAP kinase kinase 6) |
| Specificity: |
This is a highly specific antibody against MEK6 (MAP kinase kinase 6) |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
AF8B6 |
| Concentration: |
2ug/ul |
| Source: |
Recombinant human protein purified from E, coli (His-MEK6) |
| Gene ID number: |
5608 |
| Swiss Prot: |
P52564 |
| Tested Applications: |
IP, WB |
| Recommended dilutions: |
0 ug/ml) IP (2 ug), WB (2 |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts also as a regulator for melanocytes dendricity, Especially, Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, MAP2K6/MKK6 also phosphorylates and activates PAK6, MAP2K6/MKK6 mediates apoptotic cell death in thymocytes, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses, Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1, The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors, The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction, With MAP3K3/MKK3, Within the p38 MAPK signal transduction pathway, and for IFNG-dependent gene transcription, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, through the modulation of Rho family GTPases, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF, Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway |
| Purification method: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Dual specificity mitogen-activated protein kinase kinase 6, MAP kinase kinase 6, MAP2K6, MAPK/ERK kinase 6, MAPKK 6, MAPKK6, MEK 6, MKK6, PRKMK6, SAPK kinase 3, SAPKK-3, SAPKK3, SKK3, Stress-activated protein kinase kinase 3, MEK6 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
MEK6 (MAP kinase kinase 6) (AF8B6) Monoclonal |
| Short name: |
MEK6 (MAP kinase kinase 6) (AF8B6) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MEK6 (mitogen-stimulated protein kinase phosphorylation catalyst kinase 6) (AF8B6) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6846 |
| Gene: |
MAP2K6 |
More about : MAP2K6 |
| Long gene name: |
mitogen-activated protein kinase kinase 6 |
| Synonyms gene: |
PRKMK6 |
| Synonyms: |
MEK6 MKK6 SAPKK3 MAPKK6 |
| Synonyms name: |
kinase 6 (MAP kinase kinase 6) , mitogen-activated, protein kinase |
| Locus: |
17q24, 3 |
| Discovery year: |
1997-11-11 |
| GenBank acession: |
U39064 |
| Entrez gene record: |
5608 |
| Pubmed identfication: |
8621675 |
| RefSeq identity: |
NM_002758 |
| Classification: |
Mitogen-activated protein kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000180311 |