| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
MEK6 (MKK6) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the MEK6 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This MEK6 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P52564 |
| Purity: |
Antigen affinity |
| Description: |
Han et al, MKK6 is a member of the dual specificity protein kinase family, Mukherjee et al, They proposed that ser and/or thr acetylation by a bacterial effector may be a mechanism that occurs in other signaling pathways, also known as MAP kinase kinase 6 (MAPKK6 or MKK6) and MAPK/ERK kinase 6 (MEK6) is an enzyme that in humans is encoded by the MAP2K6 gene, on chromosome 17, thereby blocking phosphorylation and kinase activation, using coenzyme A to modify critical ser and thr residues in the MKK6 activation loop, which functions as a mitogen-activated protein (MAP) kinase kinase, (1996) described experiments addressing the function of MKK6 in intracellular signaling pathways leading toward activation of p38 MAPK, (2006) found that the Yersinia YopJ virulence factor acted as an acetyltransferase, MAP2K6 (Mitogen-activated protein kinase kinase 6) |
| Immunogen: |
An amino acid sequence from the N-terminus of human MKK6/MEK6 (KKRNPGLKIPKEAFEQP) was used as the immunogen for this MEK6 antibody (100% mouse homology) |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the MEK6 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
MEK6 (MKK6) |
| Short name: |
MEK6 Antibody (MKK6) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MEK6 (Antibody to) (MKK6) |
| Alternative technique: |
antibodies |
| Identity: |
6846 |
| Gene: |
MAP2K6 |
More about : MAP2K6 |
| Long gene name: |
mitogen-activated protein kinase kinase 6 |
| Synonyms gene: |
PRKMK6 |
| Synonyms: |
MEK6 MKK6 SAPKK3 MAPKK6 |
| Synonyms name: |
kinase 6 (MAP kinase kinase 6) , mitogen-activated, protein kinase |
| Locus: |
17q24, 3 |
| Discovery year: |
1997-11-11 |
| GenBank acession: |
U39064 |
| Entrez gene record: |
5608 |
| Pubmed identfication: |
8621675 |
| RefSeq identity: |
NM_002758 |
| Classification: |
Mitogen-activated protein kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000180311 |